Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu klinické zkoušky, časopisecké články, práce podpořená grantem
PubMed
20406045
DOI
10.33549/physiolres.931893
PII: 931893
Knihovny.cz E-zdroje
- MeSH
- C-peptid krev MeSH
- diabetes mellitus 2. typu diagnóza metabolismus MeSH
- diagnostické techniky endokrinologické * MeSH
- dietní proteiny farmakologie MeSH
- dietní tuky farmakologie MeSH
- dospělí MeSH
- glukózový toleranční test MeSH
- glykovaný hemoglobin metabolismus MeSH
- hyperglykemie diagnóza metabolismus MeSH
- inzulin krev MeSH
- konzumní sacharóza farmakologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita diagnóza metabolismus MeSH
- senioři MeSH
- žaludeční inhibiční polypeptid krev metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- C-peptid MeSH
- dietní proteiny MeSH
- dietní tuky MeSH
- glykovaný hemoglobin MeSH
- hemoglobin A1c protein, human MeSH Prohlížeč
- inzulin MeSH
- konzumní sacharóza MeSH
- žaludeční inhibiční polypeptid MeSH
Glucose-dependent insulinotropic peptide (GIP) contributes to incretin effect of insulin secretion which is impaired in Type 2 diabetes mellitus. The aim of this study was to introduce a simple meal test for evaluation of GIP secretion and action and to examine GIP changes in Type 2 diabetic patients. Seventeen Type 2 diabetic patients, 10 obese non-diabetic and 17 non-obese control persons have been examined before and after 30, 60 and 90 min stimulation by meal test. Serum concentrations of insulin, C-peptide and GIP were estimated during the test. Impaired GIP secretion was found in Type 2 diabetic patients as compared with obese non-diabetic and non-obese control persons. The AUCGIP during 90 min of the meal stimulation was significantly lower in diabetic patients than in other two groups (p<0.03). Insulin concentration at 30 min was lower in diabetic than in non-diabetic persons and the GIP action was delayed. The deltaIRI/deltaGIP ratio increased during the test in diabetic patients, whereas it progressively decreased in obese and non-obese control persons. Simple meal test could demonstrate impaired GIP secretion and delayed insulin secretion in Type 2 diabetic patients as compared to obese non-diabetic and non-obese healthy control individuals.
3rd Department of Internal Medicine 1st Faculty of Medicine Charles University Prague Czech Republic
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