Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients
Language English Country Czech Republic Media print-electronic
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
20406045
DOI
10.33549/physiolres.931893
PII: 931893
Knihovny.cz E-resources
- MeSH
- C-Peptide blood MeSH
- Diabetes Mellitus, Type 2 diagnosis metabolism MeSH
- Diagnostic Techniques, Endocrine * MeSH
- Dietary Proteins pharmacology MeSH
- Dietary Fats pharmacology MeSH
- Adult MeSH
- Glucose Tolerance Test MeSH
- Glycated Hemoglobin metabolism MeSH
- Hyperglycemia diagnosis metabolism MeSH
- Insulin blood MeSH
- Dietary Sucrose pharmacology MeSH
- Middle Aged MeSH
- Humans MeSH
- Obesity diagnosis metabolism MeSH
- Aged MeSH
- Gastric Inhibitory Polypeptide blood metabolism MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- C-Peptide MeSH
- Dietary Proteins MeSH
- Dietary Fats MeSH
- Glycated Hemoglobin A MeSH
- hemoglobin A1c protein, human MeSH Browser
- Insulin MeSH
- Dietary Sucrose MeSH
- Gastric Inhibitory Polypeptide MeSH
Glucose-dependent insulinotropic peptide (GIP) contributes to incretin effect of insulin secretion which is impaired in Type 2 diabetes mellitus. The aim of this study was to introduce a simple meal test for evaluation of GIP secretion and action and to examine GIP changes in Type 2 diabetic patients. Seventeen Type 2 diabetic patients, 10 obese non-diabetic and 17 non-obese control persons have been examined before and after 30, 60 and 90 min stimulation by meal test. Serum concentrations of insulin, C-peptide and GIP were estimated during the test. Impaired GIP secretion was found in Type 2 diabetic patients as compared with obese non-diabetic and non-obese control persons. The AUCGIP during 90 min of the meal stimulation was significantly lower in diabetic patients than in other two groups (p<0.03). Insulin concentration at 30 min was lower in diabetic than in non-diabetic persons and the GIP action was delayed. The deltaIRI/deltaGIP ratio increased during the test in diabetic patients, whereas it progressively decreased in obese and non-obese control persons. Simple meal test could demonstrate impaired GIP secretion and delayed insulin secretion in Type 2 diabetic patients as compared to obese non-diabetic and non-obese healthy control individuals.
3rd Department of Internal Medicine 1st Faculty of Medicine Charles University Prague Czech Republic
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