CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20643596
DOI
10.1016/j.canep.2010.06.008
PII: S1877-7821(10)00114-1
Knihovny.cz E-resources
- MeSH
- Checkpoint Kinase 2 MeSH
- Exons MeSH
- Genetic Predisposition to Disease MeSH
- Humans MeSH
- Pancreatic Neoplasms enzymology epidemiology genetics MeSH
- Protein Serine-Threonine Kinases genetics MeSH
- Sequence Deletion MeSH
- Case-Control Studies MeSH
- Protein Structure, Tertiary MeSH
- Genes, Tumor Suppressor MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Checkpoint Kinase 2 MeSH
- CHEK2 protein, human MeSH Browser
- Protein Serine-Threonine Kinases MeSH
Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR=5.14; 95% CI=0.94-28.23) but the observed association was non-significant (p=0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population.
Toxicogenomics Unit National Institute of Public Health Srobarova 48 100 42 Prague 10 Czech Republic
References provided by Crossref.org
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate
