CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20643596
DOI
10.1016/j.canep.2010.06.008
PII: S1877-7821(10)00114-1
Knihovny.cz E-zdroje
- MeSH
- checkpoint kinasa 2 MeSH
- exony MeSH
- genetická predispozice k nemoci MeSH
- lidé MeSH
- nádory slinivky břišní enzymologie epidemiologie genetika MeSH
- protein-serin-threoninkinasy genetika MeSH
- sekvenční delece MeSH
- studie případů a kontrol MeSH
- terciární struktura proteinů MeSH
- tumor supresorové geny MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- checkpoint kinasa 2 MeSH
- CHEK2 protein, human MeSH Prohlížeč
- protein-serin-threoninkinasy MeSH
Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR=5.14; 95% CI=0.94-28.23) but the observed association was non-significant (p=0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population.
Toxicogenomics Unit National Institute of Public Health Srobarova 48 100 42 Prague 10 Czech Republic
Citace poskytuje Crossref.org
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate
