Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II) and palladium(II) oxalato complexes with adenine derivatives as carrier ligands
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20673688
DOI
10.1016/j.jinorgbio.2010.07.002
PII: S0162-0134(10)00154-6
Knihovny.cz E-resources
- MeSH
- Adenine analogs & derivatives chemistry MeSH
- Cisplatin pharmacology MeSH
- HeLa Cells MeSH
- Hepatocytes cytology drug effects MeSH
- Inhibitory Concentration 50 MeSH
- Carboplatin pharmacology MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Molecular Structure MeSH
- Cell Line, Tumor MeSH
- Organometallic Compounds chemical synthesis chemistry pharmacology MeSH
- Organoplatinum Compounds pharmacology MeSH
- Oxaliplatin MeSH
- Palladium chemistry MeSH
- Platinum chemistry MeSH
- Antineoplastic Agents chemical synthesis chemistry pharmacology MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenine MeSH
- Cisplatin MeSH
- Carboplatin MeSH
- Organometallic Compounds MeSH
- Organoplatinum Compounds MeSH
- Oxaliplatin MeSH
- Palladium MeSH
- Platinum MeSH
- Antineoplastic Agents MeSH
In vitro antitumour activity of the [Pt(ox)(L(n))(2)] (1-7) and [Pd(ox)(L(n))(2)] (8-14) oxalato (ox) complexes involving N6-benzyl-9-isopropyladenine-based N-donor carrier ligands (L(n)) against ovarian carcinoma (A2780), cisplatin resistant ovarian carcinoma (A2780cis), malignant melanoma (G-361), lung carcinoma (A549), cervix epitheloid carcinoma (HeLa), breast adenocarcinoma (MCF7) and osteosarcoma (HOS) human cancer cell lines was studied. Some of the tested complexes were even several times more cytotoxic as compared with cisplatin employed as a positive control. The improved cytotoxic effect was demonstrated for the platinum(II) complexes 3 (IC(50)=3.2+/-1.0 microM and 3.2+/-0.6 microM) and 5 (IC(50)=4.0+/-1.0 microM and 4.1+/-1.4 microM) against A2780 and A2780cis, as compared with 11.5+/-1.6 microM, and 30.3+/-6.1 microM determined for cisplatin, respectively. The significant in vitro cytotoxicity against MCF7 (IC(50)=8.2+/-3.8 microM for 12) and A2780 (IC(50)=5.4+/-1.2 microM for 14) was evaluated for the palladium(II) oxalato complexes, which again exceeded cisplatin, whose IC(50) equalled 19.6+/-4.3 microM against the MCF7 cells. Selected complexes were also screened for their in vitro cytotoxic effect in primary cultures of human hepatocytes and they were found to be non-hepatotoxic.
Department of Cell Biology and Genetics Faculty of Science Palacký University Olomouc Czech Republic
References provided by Crossref.org
Gold(I) complexes of 9-deazahypoxanthine as selective antitumor and anti-inflammatory agents
Pharmacological and molecular effects of platinum(II) complexes involving 7-azaindole derivatives
2-Chloro-6-[(2,4-dimeth-oxy-benz-yl)amino]-9-isopropyl-9H-purine
