The noncanonical Gag domains p8 and n are critical for assembly and release of mouse mammary tumor virus
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20739518
PubMed Central
PMC2953144
DOI
10.1128/jvi.00652-10
PII: JVI.00652-10
Knihovny.cz E-zdroje
- MeSH
- genové produkty gag fyziologie MeSH
- myši MeSH
- sestavení viru * MeSH
- terciární struktura proteinů MeSH
- virové plášťové proteiny MeSH
- virus myšího tumoru prsní žlázy fyziologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- genové produkty gag MeSH
- virové plášťové proteiny MeSH
The mouse mammary tumor virus (MMTV) Gag contains the unique domains pp21, p3, p8, and n. We investigated the contribution of these domains to particle assembly and found that the region spanning the p8 and n domains is critical for shape determination and assembly. Deletion of pp21 and p3 reduced the number of released particles, but deletion of the n domain resulted in frequent formation of aberrant particles, while deletion of p8 severely impaired assembly. Further investigation of p8 revealed that both the basic and the proline-rich motifs within p8 contribute to MMTV assembly.
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