The lipid peroxidation products as possible markers of Alzheimer's disease in blood
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20920571
DOI
10.1016/j.exger.2010.09.015
PII: S0531-5565(10)00346-3
Knihovny.cz E-resources
- MeSH
- Alzheimer Disease diagnosis metabolism MeSH
- Biomarkers metabolism MeSH
- Erythrocytes metabolism MeSH
- Spectrometry, Fluorescence MeSH
- Humans MeSH
- Lipofuscin metabolism MeSH
- Oxidative Stress physiology MeSH
- Lipid Peroxidation physiology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Chromatography, High Pressure Liquid MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Lipofuscin MeSH
Oxidative stress, which is present in Alzheimer's disease (AD), results in the formation of various end-products of free radical reactions with proteins and lipids. At present there are no reliable diagnostic biomarkers of AD in the blood. Therefore, specific products of lipid peroxidation in the blood of AD patients were investigated. Lipophilic extracts of erythrocytes in the group of patients with AD (n = 44) and age-matched controls (n = 16) were studied. The end-products of lipid peroxidation, so called lipofuscin-like pigments (LFP), were analysed by fluorescence spectroscopy. It was found that the level of these products is significantly increased in erythrocytes of AD patients compared to controls. LFP were further separated by means of HPLC into individual fractions to study their composition in AD and controls. The specific fraction of LFP in AD patients, which was isolated, might represent a disease-specific product in the blood.
Exp Gerontol. 2012 May;47(5):410 PubMed
References provided by Crossref.org
Analysis of lipophilic fluorescent products in blood of Alzheimer's disease patients
Blood markers of oxidative stress in Alzheimer's disease
