The lipid peroxidation products as possible markers of Alzheimer's disease in blood
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20920571
DOI
10.1016/j.exger.2010.09.015
PII: S0531-5565(10)00346-3
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc diagnóza metabolismus MeSH
- biologické markery metabolismus MeSH
- erytrocyty metabolismus MeSH
- fluorescenční spektrometrie MeSH
- lidé MeSH
- lipofuscin metabolismus MeSH
- oxidační stres fyziologie MeSH
- peroxidace lipidů fyziologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- lipofuscin MeSH
Oxidative stress, which is present in Alzheimer's disease (AD), results in the formation of various end-products of free radical reactions with proteins and lipids. At present there are no reliable diagnostic biomarkers of AD in the blood. Therefore, specific products of lipid peroxidation in the blood of AD patients were investigated. Lipophilic extracts of erythrocytes in the group of patients with AD (n = 44) and age-matched controls (n = 16) were studied. The end-products of lipid peroxidation, so called lipofuscin-like pigments (LFP), were analysed by fluorescence spectroscopy. It was found that the level of these products is significantly increased in erythrocytes of AD patients compared to controls. LFP were further separated by means of HPLC into individual fractions to study their composition in AD and controls. The specific fraction of LFP in AD patients, which was isolated, might represent a disease-specific product in the blood.
Exp Gerontol. 2012 May;47(5):410 PubMed
Citace poskytuje Crossref.org
Analysis of lipophilic fluorescent products in blood of Alzheimer's disease patients
Blood markers of oxidative stress in Alzheimer's disease
