Perivascular sirolimus-delivery system
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21075185
DOI
10.1016/j.ijpharm.2010.11.005
PII: S0378-5173(10)00854-9
Knihovny.cz E-resources
- MeSH
- Coated Materials, Biocompatible * MeSH
- Chemistry, Pharmaceutical MeSH
- Technology, Pharmaceutical methods MeSH
- Cardiovascular Agents administration & dosage chemistry pharmacology MeSH
- Kinetics MeSH
- Rats MeSH
- Cells, Cultured MeSH
- Delayed-Action Preparations MeSH
- Microscopy, Electron, Scanning MeSH
- Molecular Weight MeSH
- Myocytes, Smooth Muscle drug effects MeSH
- Drug Carriers * MeSH
- Graft Occlusion, Vascular prevention & control MeSH
- Polyesters chemistry MeSH
- Rats, Wistar MeSH
- Surface Properties MeSH
- Drug Compounding MeSH
- Cell Proliferation drug effects MeSH
- Solubility MeSH
- Sirolimus administration & dosage chemistry pharmacology MeSH
- Drug Stability MeSH
- Muscle, Smooth, Vascular drug effects MeSH
- Chromatography, High Pressure Liquid MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Coated Materials, Biocompatible * MeSH
- Cardiovascular Agents MeSH
- lactide-caprolactone copolymer MeSH Browser
- Delayed-Action Preparations MeSH
- Drug Carriers * MeSH
- Polyesters MeSH
- Sirolimus MeSH
Autologous vein grafts are often used for treating damaged vessels, e.g. arteriovenous fistulas or arterial bypass conduits. Veins have a different histological structure from arteries, which often leads to intimal hyperplasia and graft restenosis. The aim of this study was to develop a perivascular sirolimus-delivery system that would release the antiproliferative drug sirolimus in a controlled manner. Polyester Mesh I was coated with purasorb, i.e. a copolymer of L-lactide and ɛ-caprolactone, with dissolved sirolimus; Mesh II was coated with two copolymer layers; the layer with dissolved sirolimus was overlaid with pure purasorb. This arrangement allowed sirolimus to be released for 6 and 4 weeks, for Mesh I and Mesh II, respectively. Mesh II released sirolimus more homogeneously, without the initial burst effect during the first week. However, the cumulative release curve was steeper at later time points than the curve for Mesh I. Both meshes inhibited proliferation of rat vascular smooth muscle cells during 14-day culture in vitro and preserved excellent cell viability. Newly developed sirolimus-releasing perivascular meshes are promising devices for preventing autologous graft restenosis.
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