Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients
Language English Country England, Great Britain Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
21440298
DOI
10.1016/j.leukres.2011.03.001
PII: S0145-2126(11)00117-2
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Immunophenotyping MeSH
- Middle Aged MeSH
- Humans MeSH
- Multiple Myeloma metabolism MeSH
- Biomarkers, Tumor metabolism MeSH
- Neoplastic Stem Cells metabolism MeSH
- Nestin MeSH
- Pilot Projects MeSH
- Plasma Cells metabolism MeSH
- Prognosis MeSH
- Intermediate Filament Proteins metabolism MeSH
- Nerve Tissue Proteins metabolism MeSH
- Flow Cytometry MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Blotting, Western MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
- NES protein, human MeSH Browser
- Nestin MeSH
- Intermediate Filament Proteins MeSH
- Nerve Tissue Proteins MeSH
Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138(+)CD38(+) plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma.
References provided by Crossref.org
Nestin as a marker of cancer stem cells
