Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients

. 2011 Aug ; 35 (8) : 1008-13. [epub] 20110326

Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid21440298
Odkazy

PubMed 21440298
DOI 10.1016/j.leukres.2011.03.001
PII: S0145-2126(11)00117-2
Knihovny.cz E-zdroje

Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138(+)CD38(+) plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma.

Citace poskytuje Crossref.org

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