Antibody response to chlamydiae in children with asthma and respiratory illness
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- bronchiální astma imunologie MeSH
- Chlamydia trachomatis imunologie izolace a purifikace MeSH
- chlamydiové infekce imunologie MeSH
- Chlamydophila pneumoniae imunologie izolace a purifikace MeSH
- dítě MeSH
- ELISA MeSH
- imunoglobulin A krev MeSH
- imunoglobulin G krev MeSH
- imunoglobulin M krev MeSH
- infekce dýchací soustavy imunologie mikrobiologie MeSH
- konjunktiva mikrobiologie MeSH
- lidé MeSH
- mladiství MeSH
- nazofarynx mikrobiologie MeSH
- předškolní dítě MeSH
- protilátky bakteriální krev MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- imunoglobulin A MeSH
- imunoglobulin G MeSH
- imunoglobulin M MeSH
- protilátky bakteriální MeSH
No relation between the occurrence of antibodies to chlamydial agents and asthma in children was found. In asthmatic children, the antibodies to Chlamydia trachomatis occurred in 3.1% and to Chlamydophila pneumoniae in 22.7%, whereas in a control group of children without asthma or other allergic disease in 2.3% and 24.0%, respectively. The occurrence of antibodies of IgA and IgG classes to C. pneumoniae was also very similar; its rise was age-dependent. On the other hand, in the group of children in a pre-school age with respiratory tract infection, anti-chlamydial antibodies were demonstrated significantly more often (18.5% of IgG antibodies to C. trachomatis, 20.0% of IgM antibodies to both C. trachomatis and C. pneumoniae) than in those suffering from other, non-respiratory illness (3.9% of the former and 5.9% of the latter antibodies). However, in these children, we did not succeed in detection of C. trachomatis in conjunctival and nasopharyngeal smears by PCR. Nevertheless, chlamydial agents (C. trachomatis in infants, C. pneumoniae in pre-school children) should be taken into consideration in a differential diagnosis of respiratory tract inflammation.
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