Antibody response to chlamydiae in children with asthma and respiratory illness
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Asthma immunology MeSH
- Chlamydia trachomatis immunology isolation & purification MeSH
- Chlamydia Infections immunology MeSH
- Chlamydophila pneumoniae immunology isolation & purification MeSH
- Child MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Immunoglobulin A blood MeSH
- Immunoglobulin G blood MeSH
- Immunoglobulin M blood MeSH
- Respiratory Tract Infections immunology microbiology MeSH
- Conjunctiva microbiology MeSH
- Humans MeSH
- Adolescent MeSH
- Nasopharynx microbiology MeSH
- Child, Preschool MeSH
- Antibodies, Bacterial blood MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immunoglobulin A MeSH
- Immunoglobulin G MeSH
- Immunoglobulin M MeSH
- Antibodies, Bacterial MeSH
No relation between the occurrence of antibodies to chlamydial agents and asthma in children was found. In asthmatic children, the antibodies to Chlamydia trachomatis occurred in 3.1% and to Chlamydophila pneumoniae in 22.7%, whereas in a control group of children without asthma or other allergic disease in 2.3% and 24.0%, respectively. The occurrence of antibodies of IgA and IgG classes to C. pneumoniae was also very similar; its rise was age-dependent. On the other hand, in the group of children in a pre-school age with respiratory tract infection, anti-chlamydial antibodies were demonstrated significantly more often (18.5% of IgG antibodies to C. trachomatis, 20.0% of IgM antibodies to both C. trachomatis and C. pneumoniae) than in those suffering from other, non-respiratory illness (3.9% of the former and 5.9% of the latter antibodies). However, in these children, we did not succeed in detection of C. trachomatis in conjunctival and nasopharyngeal smears by PCR. Nevertheless, chlamydial agents (C. trachomatis in infants, C. pneumoniae in pre-school children) should be taken into consideration in a differential diagnosis of respiratory tract inflammation.
See more in PubMed
Eur J Intern Med. 2009 Oct;20(6):579-85 PubMed
Cent Eur J Public Health. 2000 Aug;8(3):169-71 PubMed
Thorax. 2002 Aug;57(8):672-6 PubMed
Ann Ital Med Int. 2004 Oct-Dec;19(4):249-61 PubMed
J Infect Dis. 1988 Nov;158(5):1095-7 PubMed
N Engl J Med. 1977 Feb 10;296(6):306-10 PubMed
N Engl J Med. 1986 Jul 17;315(3):161-8 PubMed
Pharmacol Ther. 2004 Mar;101(3):193-210 PubMed
J Allergy Clin Immunol. 2000 Feb;105(2 Pt 1):391-2 PubMed
Am J Respir Crit Care Med. 2005 Nov 1;172(9):1078-89 PubMed
Paediatr Drugs. 2001;3(3):159-68 PubMed
Epidemiol Mikrobiol Imunol. 1994 Sep;43(3):111-3 PubMed
J Infect Dis. 1998 Mar;177(3):720-4 PubMed
J Allergy Clin Immunol. 2005 Nov;116(5):1123-8 PubMed
Respir Med. 2005 Jan;99(1):20-6 PubMed
Eur J Clin Microbiol Infect Dis. 1989 Mar;8(3):191-202 PubMed
Eur Respir J. 1998 Feb;11(2):345-9 PubMed
Ann Allergy Asthma Immunol. 1998 Oct;81(4):339-44 PubMed
Curr Infect Dis Rep. 2000 Apr;2(2):115-120 PubMed
