The microbial load with genital mycoplasmas correlates with the degree of histologic chorioamnionitis in preterm PROM
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21663889
DOI
10.1016/j.ajog.2011.04.028
PII: S0002-9378(11)00514-X
Knihovny.cz E-resources
- MeSH
- Bacterial Load * MeSH
- Chorioamnionitis microbiology pathology MeSH
- Adult MeSH
- Humans MeSH
- Mycoplasma physiology MeSH
- Mycoplasma Infections microbiology pathology MeSH
- Amniotic Fluid microbiology MeSH
- Fetal Membranes, Premature Rupture microbiology pathology MeSH
- Prospective Studies MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVE: We sought to determine whether there is an association between bacterial load of genital mycoplasmas and histologic chorioamnionitis (HCA) in women with preterm premature rupture of membranes (PPROM). STUDY DESIGN: A total of 103 women with PPROM between 24-36 weeks of gestation were included in the study. Amniocenteses were performed, and the amounts of target genital mycoplasma DNA in amniotic fluid samples were evaluated using real-time polymerase chain reaction. The bacterial load of the genital mycoplasmas was relatively assessed using the threshold cycle value. RESULTS: The presence of genital mycoplasmas in amniotic fluid was found in 38% (39/103) of the women. The presence of HCA was associated with lower threshold cycle values (median 21.3, interquartile range, 16.5-28.5, vs median 29.4, interquartile range, 27.0-30.5; P = .005). CONCLUSION: HCA in PPROM is associated with a higher bacterial load of genital mycoplasmas.
References provided by Crossref.org
Cervical Gardnerella vaginalis in women with preterm prelabor rupture of membranes
Late preterm prelabor rupture of fetal membranes: fetal inflammatory response and neonatal outcome
Maternal Serum C-Reactive Protein in Women with Preterm Prelabor Rupture of Membranes
Intraamniotic Inflammation in Women with Preterm Prelabor Rupture of Membranes
Cervical microbiota in women with preterm prelabor rupture of membranes