OBJECTIVE: We sought to determine whether there is an association between bacterial load of genital mycoplasmas and histologic chorioamnionitis (HCA) in women with preterm premature rupture of membranes (PPROM). STUDY DESIGN: A total of 103 women with PPROM between 24-36 weeks of gestation were included in the study. Amniocenteses were performed, and the amounts of target genital mycoplasma DNA in amniotic fluid samples were evaluated using real-time polymerase chain reaction. The bacterial load of the genital mycoplasmas was relatively assessed using the threshold cycle value. RESULTS: The presence of genital mycoplasmas in amniotic fluid was found in 38% (39/103) of the women. The presence of HCA was associated with lower threshold cycle values (median 21.3, interquartile range, 16.5-28.5, vs median 29.4, interquartile range, 27.0-30.5; P = .005). CONCLUSION: HCA in PPROM is associated with a higher bacterial load of genital mycoplasmas.

Department of Obstetrics and Gynecology Charles University Prague Czech Republic

Citace poskytuje Crossref.org

Cervical Gardnerella vaginalis in women with preterm prelabor rupture of membranes

Late preterm prelabor rupture of fetal membranes: fetal inflammatory response and neonatal outcome

Maternal white blood cell count cannot identify the presence of microbial invasion of the amniotic cavity or intra-amniotic inflammation in women with preterm prelabor rupture of membranes

Maternal Serum C-Reactive Protein in Women with Preterm Prelabor Rupture of Membranes

Intraamniotic Inflammation in Women with Preterm Prelabor Rupture of Membranes

Cervical microbiota in women with preterm prelabor rupture of membranes

Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria