Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- aktivace lymfocytů MeSH
- Borrelia burgdorferi komplex imunologie MeSH
- CD4-pozitivní T-lymfocyty imunologie MeSH
- cytokiny metabolismus MeSH
- dendritické buňky imunologie MeSH
- fagocytóza MeSH
- imunologické faktory imunologie MeSH
- klíště mikrobiologie MeSH
- myši inbrední C3H MeSH
- myši MeSH
- sliny imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cytokiny MeSH
- imunologické faktory MeSH
Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia-stimulated DCs and the ability of Borrelia-exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia-exposed DCs to induce both proliferation and IL-2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF-α and IL-6) and Th2 (IL-10) cytokines by DCs. Our data reveal a complex inhibitory effect of tick saliva on Borrelia-DCs interaction.
Citace poskytuje Crossref.org
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