Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Lymphocyte Activation MeSH
- Borrelia burgdorferi Group immunology MeSH
- CD4-Positive T-Lymphocytes immunology MeSH
- Cytokines metabolism MeSH
- Dendritic Cells immunology MeSH
- Phagocytosis MeSH
- Immunologic Factors immunology MeSH
- Ixodes microbiology MeSH
- Mice, Inbred C3H MeSH
- Mice MeSH
- Saliva immunology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cytokines MeSH
- Immunologic Factors MeSH
Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia-stimulated DCs and the ability of Borrelia-exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia-exposed DCs to induce both proliferation and IL-2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF-α and IL-6) and Th2 (IL-10) cytokines by DCs. Our data reveal a complex inhibitory effect of tick saliva on Borrelia-DCs interaction.
References provided by Crossref.org
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells
Modulation of host immunity by tick saliva
Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes
