APOE polymorphism as a potential determinant of functional fitness in the elderly regardless of nutritional status
Language English Country Sweden Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22101883
PII: NEL320811A10
Knihovny.cz E-resources
- MeSH
- Apolipoprotein E2 genetics MeSH
- Apolipoprotein E3 genetics MeSH
- Apolipoprotein E4 genetics MeSH
- Apolipoproteins E genetics MeSH
- Longevity genetics MeSH
- Genetic Fitness genetics MeSH
- Heterozygote MeSH
- Risk Assessment MeSH
- Real-Time Polymerase Chain Reaction MeSH
- Humans MeSH
- Logistic Models MeSH
- Life Expectancy MeSH
- Nutritional Status MeSH
- Polymorphism, Genetic genetics MeSH
- Aged, 80 and over MeSH
- Aged physiology MeSH
- Physical Fitness MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged physiology MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Apolipoprotein E2 MeSH
- Apolipoprotein E3 MeSH
- Apolipoprotein E4 MeSH
- Apolipoproteins E MeSH
OBJECTIVES: Life expectancy is determined by a combination of genetic predisposition (~25%) and environmental influences (~75%). Nevertheless a stronger genetic influence is anticipated in long-living individuals. Apolipoprotein E (APOE) gene belongs among the most studied candidate genes of longevity. We evaluated the relation of APOE polymorphism and fitness status in the elderly. MATERIAL AND METHODS: We examined a total number of 128 subjects, over 80 years of age. Using a battery of functional tests their fitness status was assessed and the subjects were stratified into 5 functional categories according to Spirduso´s classification. Biochemistry analysis was performed by enzymatic method using automated analyzers. APOE gene polymorphism was analysed performed using PCR-RFLP. RESULTS: APOE4 allele carriers had significantly worse fitness status compared to non-carriers (p=0.025). Multiple logistic regression analysis showed the APOE4 carriers had higher risk (p=0.05) of functional unfitness compared to APOE2/E3 individuals. CONCLUSIONS: APOE gene polymorphism seems be an important genetic contributor to frailty development in the elderly. While APOE2 carriers tend to remain functionally fit till higher age, the functional status of APOE4 carriers deteriorates more rapidly.
