BACKGROUND: The Czech Unplugged Study, inspired by the European Drug Addiction Prevention Trial, is a prospective, school-based, randomized controlled prevention trial designed to reduce the risk of alcohol, tobacco, inhalant, and illegal drug use in 6th graders in the Czech Republic. The intervention uses the comprehensive social influence model to affect alcohol and drug using norms among primary school students. METHODS: Descriptive statistics and chi-square analyses were used to assess differences between the experimental and control groups on demographic characteristics and study outcomes. Multilevel techniques were used to take the hierarchical structure of the data into account. Prevalence odds ratios using the Bonferroni correction were calculated to assess the differences between the experimental (N = 914) and control (N = 839) groups on each outcome 1, 3, 12, 15, and 24 months after the end of the intervention. RESULTS: Multilevel analysis using the Bonferroni correction showed statistically significant intervention effects at the final follow-up for any smoking (OR = 0.75, 99.2% CI 0.65-0.87), daily smoking (OR = 0.62, 99.2% CI 0.48-0.79), heavy smoking (OR = 0.48, 99.2% CI 0.28-0.81), any cannabis use (OR = 0.57 99.2% CI 0.42-0.77), frequent cannabis use (OR = 0.57, 99.2% CI 0.36-0.89), and any drug use (OR = 0.78, 99.2% CI 0.65-0.94). CONCLUSIONS: This study adds new evidence on the effectiveness of the Unplugged school-based prevention program for primary school students in the Czech Republic.

Center for Addictology 1st Faculty of Medicine Charles University Prague Ke Karlovu 11 120 00 Praha 2 Czech Republic

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Adamkova T, Jurystova L, Gabrhelik R, Miovska L, Miovsky M. Primární prevence na školách zapojených do projektu EUDAP 2. Adiktologie. 2009;9:86–94.

Botvin GJ. Prevention of adolescent substance abuse though the development of personal and social competence. In: Glynn T, Leukefeld C, Ludford JP, editors. Preventing Adolescent Drug Abuse: Intervention Strategies. NIDA; Rockville, MD: 1983. pp. 115–140. PubMed

Brook DW, Brook JS, Zhang C, Whiteman M, Cohen P, Finch SJ. Developmental trajectories of cigarette smoking from adolescence to the early thirties: personality and behavioral risk factors. Nicotine Tob Res. 2008;10:1283–1291. PubMed PMC

Cervenka J. Názory občanů na drogy. Centrum pro výzkum veřejného mínění; Praha: 2010.

Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. BMJ. 1995;310:452–154. PubMed PMC

Csemy L, Chomynova P, Sadilek P. Evropská školní studie o alkoholu a jiných drogách (ESPAD) – Výsledky průzkumuv České republice v roce 2007. Úřad vlády České republiky; Praha: 2009.

Csemy L, Lejckova P, Sadilek P, Sovinova H. Evropska skolni studie o alko-holu a jinych drogach (ESPAD): Výsledky prlzkumu v České republice v roce 2003. Úřad vlády České republiky; Praha: 2006.

Cuijpers P. Effective ingredients of school-based drug prevention programs. A systematic review Addict Behav. 2002;27:1009–1023. PubMed

Cuijpers P. Three decades of drug prevention research. Drugs Educ Prev Policy. 2003;10:7–12.

Dawson DA, Goldstein RB, Patricia Chou S, June Ruan W, Grant BF. Age at first drink and the first Incidence of adult-onset DSM-IV alcohol use disorders. Alcohol Clin Exp Res. 2008;32:2149–2160. PubMed PMC

Faggiano F, Galanti MR, Bohrn K, Burkhart G, Cuomo L, Vigna-Taglianti F, Fabi-ani L, Panella M, Perez T, Siliquini R, van der Kreeft P, Vassara M, Wiborg G. EU-Dap Study Group 2008. The effectiveness of a school-based substance abuse prevention program: EU-Dap cluster randomised controlled trial. Prev Med. 2008a;47:537–543. PubMed

Faggiano F, Richardson C, Bohrn K, Galanti MR EU-Dap Study Group. A cluster randomized controlled trial of school-based prevention of tobacco, alcohol and drugs use: the EU-Dap design and study population. Prev Med. 2007;44:170–173. PubMed

Faggiano F, Vigna-Taglianti F, Burkhart G, Bohrn K, Cuomo L, Gregori D, Panella M, Scatigna M, Siliquini R, Varona L, van der Kreeft P, Maro Vas-sarai M, Wiborg G, Galanti MR EU-Dap Study Group. The effectiveness of a school-based substance abuse prevention program: 18-Month follow-up of the EU-Dap cluster randomized controlled trial. Drug Alcohol Depend. 2010;108:56–64. PubMed

Faggiano F, Vigna-Taglianti FD, Versino E, Zambon A, Borraccino A, Lemma P. School-based prevention for illicit drugs use: a systematic review. Prev Med. 2008b;46:385–396. PubMed

Grant BF. Age at smoking onset and its association with alcohol consumption and DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse. 1998;10:59–73. PubMed

Grant BF, Dawson DA. Age of onset of drug use and its association with DSM-IV drug abuse and dependence: results from the national longitudinal alcohol epidemiologic survey. J Subst Abuse. 1998;10:163–173. PubMed

Hibell B, Andersson B, Bjarnason T, Ahlström S, Balakireva O, Kokkevi A, Mor-gan M. Alcohol and Other Drug Use Among Students in 35 European Countries. The Swedish Council for Information on Alcohol and Other Drugs (CAN) and the Pompidou Group at the Council of Europe; Stockholm, Sweden: 2004. The ESPAD Report 2003.

Hibell B, Guttormsson U, Ahlström S, Balakireva O, Bjarnason T, Kokkevi A, Kraus L. The 2007 ESPAD Report - Substance Use Among Students in 35 European Countries. The Swedish Council for Information on Alcohol and Other Drugs (CAN); Stockholm, Sweden: 2009.

Johnston LD, O’Malley PM, Bachman JG, Schulenberg JE. Monitoring the Future National Results on Adolescent Drug Use: Overview of Key fFndings, 2010. Institute for Social Research, The University of Michigan; Ann Arbor: 2011.

Jurystova L, Gabrhelik R, Miovsky M. Formativní evaluace procesu imple-mentace preventivního programu Unplugged školními metodiky prevence. Adiktologie. 2009;9:10–19.

Jurystova L, Miovsky M. Vybrané aspekty organizační a odborné pod-pory pedagogů při realizaci metodiky Unplugged ve školách: výsledky evaluace implementace projektu EUDAP. Adiktologie. 2010;10:146–153.

Karmelitova P, Tyc M. Praha 3, 8 a10–závěrečná zpráva z šetření. 2003. Průzkum žáků 6. –9 tříd ZŠ městských částí. Unpublished results. Praha.

Karp I, O’Loughlin J, Paradis G, Hanley J, Difranza J. Smoking trajectories of adolescent novice smokers in a longitudinal study of tobacco use. Ann Epidemiol. 2005;15:445–452. PubMed

Lejckova P, Csemy L. Pozitivni a negativni ocekavani mladeze od konzumace alkoholu. Adiktologie. 2006;6:134–143.

Little RJA, Rubin DB. Statistical Analysis with Missing Data. J. Wiley and Sons; New York: 1987.

McGuire WJ. The effectiveness of supportive and refutational defenses in immunizing defenses. Sociometry. 1961;24:184–197.

Miovska L. Drugs in Focus 2. Úřad vlády České republiky; Praha: 2005. Užívání drog v národnostních menšinách v ČR–Souhrn dos-tupných informací.

Miovska L, Miovsky M, Vaclavkova B. Závěrečná zpráva. 2008. Přehled hlavních výsledků kvaziexperimentální evaluační studie komunitního programu primární prevence. Centrum adiktologie PK 1. LF UK v Praze/o.s. Prev-centrum.

Miovsky M, Stastna L, Gabrheliík R, Jurystova L. Evaluation of the Drug Prevention Interventions in the Czech Republic. Adiktologie. 2011;11:236–247.

Miovsky M, Miovska L, Rehan V, Trapkova B. Substance use in fifth- and seventh-grade basic school pupils: review of results of quasiexperimental evaluation study. Cesk Psychol. 2007;51:109–118.

Miovsky M, Miovska L, Trapkova B, Rehan V. Užívání alkoholu u dětí 5. a 7 tříd základních škol: výsledky kvaziexperimentální evaluační studie. Adiktologie. 2006;6:162–173.

O’Malley PM, Johnston LD, Bachman JG, Schulenberg J. A comparison of confidential versus anonymous survey procedures: effects on reporting of drug use and related attitudes and beliefs in a national study of students. J Drug Issues. 2000;30:35–54.

Park J, Kosterman R, Hawkins JD, Haggerty KP, Duncan TE, Duncan SC, Spoth R. Effects of the preparing for the drug free years curriculum on growth in alcohol use and risk for alcohol use in early adolescence. Prev Sci. 2000;1:125–138. PubMed

Pitkänen T, Lyyra AL, Pulkkinen L. Age of onset of drinking and the use of alcohol in adulthood: a follow-up study from age 8–42 for females and males. Addiction. 2005;100:652–661. PubMed

Porath-Waller AJ, Beasley E, Beirness DJ. A meta-analytic review of school-based prevention for cannabis use. Health Educ Behav. 2010;37:709–723. PubMed

SAS Institute Inc. SAS 9.1. SAS Institute Inc; Cary, NC: 2007.

Schafer JL. Analysis of Incomplete multivariate data. Chapman and Hall; London: 1997.

Sloboda Z, Stephens RC, Stephens PC, Grey SF, Teasdale B, Hawthorne RD, Williams J, Marquette JF. The Adolescent Substance Abuse Prevention Study: a randomized field trial of a universal substance abuse prevention program. Drug Alcohol Depend. 2009;102:1–10. PubMed

Sussman S, Earleywine M, Wills T, Cody C, Biglan T, Dent CW, Newcomb MD. The motivation, skills, and decision-making model of drug abuse prevention. Subst Use Misuse. 2004;39:1971–2016. PubMed

Thomas RE, Perera R. School-based programmes for preventing smoking. Cochrane Database Syst Rev. 2006:3. PubMed PMC

Tobler NS. Meta-anaiysis of 143 adolescent drug prevention programs: quantitative outcome results of program participants compared to a control or comparison group. J Drug Issues. 1986;16:537–567.

Tobler NS, Roona MR, Ochshorn PM, Diana G, Streke AV, Stackpole KM. School-based adolescent drug prevention programs: 1998 metaanalysis. J Prim Prev. 2000;20:275–336.

van der Kreeft P, Wiborg G, Galanti MR, Siliquini R, Bohrn K, Scatigna M, Lin-dahl AM, Melero JC, Vassara M, Faggiano F. The Eu-Dap Study Group, ‘Unplugged’: a new European school programme against substance abuse. Drugs Educ Prev Policy. 2009;16:167–181.

Vigna-Taglianti F, Vadrucci S, Faggiano F, Burkhart G, Siliquini R, Galanti MR. Eu-Dap Study Group Is universal prevention against youths’ substance misuse really universal? Gender-specific effects in the EU-Dap school-based prevention trial. J Epidemiol Commun Health. 2009;63:722–728. PubMed

World Health Organization, Regional Office for Europe. HBSC International Report from the 2005/2006 Survey. WHO; Copenhagen: 2008. Inequalities in Young People‘s Health.

Measuring Parental Behavior towards Children's Use of Media and Screen-Devices: The Development and Psychometrical Properties of a Media Parenting Scale for Parents of School-Aged Children

School-Based Prevention of Screen-Related Risk Behaviors during the Long-Term Distant Schooling Caused by COVID-19 Outbreak

Universality properties of school-based preventive intervention targeted at cannabis use