Bral1: "Superglue" for the extracellular matrix in the brain white matter
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
22300985
DOI
10.1016/j.biocel.2012.01.009
PII: S1357-2725(12)00013-1
Knihovny.cz E-resources
- MeSH
- Extracellular Matrix metabolism MeSH
- Humans MeSH
- Brain cytology metabolism MeSH
- Nerve Tissue Proteins chemistry metabolism MeSH
- Gene Expression Regulation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Nerve Tissue Proteins MeSH
Bral1 is a link protein that stabilizes the binding between lecticans and hyaluronic acid and thus maintains the extracellular matrix assembly in the CNS. Bral1 is specifically located in the white matter around the nodes of Ranvier. Recent studies suggest its function in promoting saltatory neural conduction. This article reviews the current knowledge about the structure, expression and function of this link protein.
References provided by Crossref.org
