Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
22360668
DOI
10.2174/138955712798869011
PII: MRMC-12-1-24
Knihovny.cz E-zdroje
- MeSH
- antidota farmakologie terapeutické užití MeSH
- chemické bojové látky otrava MeSH
- cholinesterasové inhibitory otrava MeSH
- lidé MeSH
- oximy terapeutické užití MeSH
- reaktivátory cholinesterázy chemie farmakologie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antidota MeSH
- chemické bojové látky MeSH
- cholinesterasové inhibitory MeSH
- oximy MeSH
- reaktivátory cholinesterázy MeSH
Highly toxic organophosphorus inhibitors of acetylcholinesterase referred as nerve agents are considered to be among the most dangerous chemical warfare agents. The oximes represent very important part of medical countermeasures of nerve agent poisonings. They are used to reactivate the nerve agent-inhibited acetylcholinesterase. Despite long-term research activities, there is no single, broad-spectrum oxime suitable for the antidotal treatment of poisoning with all organophosphorus agents. There are two approaches how to increase and broaden the effectiveness of antidotal treatment of poisoning with nerve agents - to develop new structural analogues of currently available oximes and/or to combine currently available or newly developed oximes. The review describes the evaluation of the potency of newly developed oximes (especially the oxime K203) or combinations of oximes to reactivate nerve agent-inhibited acetylcholinesterase and to counteract the acute toxicity of nerve agents in comparison with single commonly used oxime (obidoxime, trimedoxime or HI-6).
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