Pregnancy-associated plasma protein A (PAPP-A) and soluble receptor for advanced glycation end products (sRAGE)--intra- and inter-individual variability in chronic hemodialysis patients
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Analysis of Variance MeSH
- Biomarkers blood MeSH
- Kidney Failure, Chronic blood complications therapy MeSH
- Renal Dialysis * MeSH
- Cardiovascular Diseases blood etiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Leukocyte Count MeSH
- Prospective Studies MeSH
- Receptor for Advanced Glycation End Products MeSH
- Receptors, Immunologic blood MeSH
- Regression Analysis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Pregnancy-Associated Plasma Protein-A metabolism MeSH
- Transferrin metabolism MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Receptor for Advanced Glycation End Products MeSH
- Receptors, Immunologic MeSH
- Pregnancy-Associated Plasma Protein-A MeSH
- Transferrin MeSH
BACKGROUND: Dialysis patients are at high risk of cardiovascular complications. Pregnancy-associated plasma protein A (PAPP-A) as well as sRAGE (soluble receptor for advanced glycation end products) are new biomarkers related to cardiovascular disease. The aim of our study was to describe their intra- and inter-individual variability. METHODS: The studied group consisted of 21 chronic hemodialysis patients. PAPP-A, sRAGE and selected routine parameters were measured monthly during a 1-year prospective study. RESULTS: Our results show high intra-individual variability of both PAPP-A and sRAGE. Both PAPP-A and sRAGE were closely linked to serum transferrin levels. Additionally, sRAGE was significantly associated with leukocyte count and haemoglobin. CONCLUSION: Our study demonstrates high intra-individual variability of PAPP-A and sRAGE in stable clinical status. This finding could be helpful for further evaluation of the significance of PAPP-A and sRAGE in chronic kidney disease.
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