Early regression of the dental lamina underlies the development of diphyodont dentitions
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
22442052
DOI
10.1177/0022034512442896
PII: 0022034512442896
Knihovny.cz E-zdroje
- MeSH
- apoptóza MeSH
- dentice trvalá * MeSH
- epitelo-mezenchymální tranzice MeSH
- epitelové buňky cytologie MeSH
- kadheriny metabolismus MeSH
- keratiny metabolismus MeSH
- matrixová metaloproteinasa 2 metabolismus MeSH
- miniaturní prasata MeSH
- odontogeneze fyziologie MeSH
- pohyb buněk MeSH
- prasata MeSH
- protoonkogenní proteiny c-myb metabolismus MeSH
- rodina transkripčních faktorů Snail MeSH
- transkripční faktory metabolismus MeSH
- vimentin metabolismus MeSH
- zubní zárodek cytologie embryologie MeSH
- zuby mléčné * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- kadheriny MeSH
- keratiny MeSH
- matrixová metaloproteinasa 2 MeSH
- protoonkogenní proteiny c-myb MeSH
- rodina transkripčních faktorů Snail MeSH
- transkripční faktory MeSH
- vimentin MeSH
Functional tooth germs in mammals, reptiles, and chondrichthyans are initiated from a dental lamina. The longevity of the lamina plays a role in governing the number of tooth generations. Monophyodont species have no replacement dental lamina, while polyphyodont species have a permanent continuous lamina. In diphyodont species, the dental lamina fragments and regresses after initiation of the second tooth generation. Regression of the lamina seems to be an important mechanism in preventing the further development of replacement teeth. Defects in the complete removal of the lamina lead to cyst formation and has been linked to ameloblastomas. Here, we show the previously unknown mechanisms behind the disappearance of the dental lamina, involving a combination of cell migration, cell-fate transformation, and apoptosis. Lamina regression starts with the loss of the basement membrane, allowing the epithelial cells to break away from the lamina and migrate into the surrounding mesenchyme. Cells deactivate epithelial markers (E-cadherin, cytokeratin), up-regulate Slug and MMP2, and activate mesenchymal markers (vimentin), while residual lamina cells are removed by apoptosis. The uncovering of the processes behind lamina degradation allows us to clarify the evolution of diphyodonty, and provides a mechanism for future manipulation of the number of tooth generations.
Citace poskytuje Crossref.org
Role of Cell Death in Cellular Processes During Odontogenesis
