Early regression of the dental lamina underlies the development of diphyodont dentitions
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22442052
DOI
10.1177/0022034512442896
PII: 0022034512442896
Knihovny.cz E-resources
- MeSH
- Apoptosis MeSH
- Dentition, Permanent * MeSH
- Epithelial-Mesenchymal Transition MeSH
- Epithelial Cells cytology MeSH
- Cadherins metabolism MeSH
- Keratins metabolism MeSH
- Matrix Metalloproteinase 2 metabolism MeSH
- Swine, Miniature MeSH
- Odontogenesis physiology MeSH
- Cell Movement MeSH
- Swine MeSH
- Proto-Oncogene Proteins c-myb metabolism MeSH
- Snail Family Transcription Factors MeSH
- Transcription Factors metabolism MeSH
- Vimentin metabolism MeSH
- Tooth Germ cytology embryology MeSH
- Tooth, Deciduous * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cadherins MeSH
- Keratins MeSH
- Matrix Metalloproteinase 2 MeSH
- Proto-Oncogene Proteins c-myb MeSH
- Snail Family Transcription Factors MeSH
- Transcription Factors MeSH
- Vimentin MeSH
Functional tooth germs in mammals, reptiles, and chondrichthyans are initiated from a dental lamina. The longevity of the lamina plays a role in governing the number of tooth generations. Monophyodont species have no replacement dental lamina, while polyphyodont species have a permanent continuous lamina. In diphyodont species, the dental lamina fragments and regresses after initiation of the second tooth generation. Regression of the lamina seems to be an important mechanism in preventing the further development of replacement teeth. Defects in the complete removal of the lamina lead to cyst formation and has been linked to ameloblastomas. Here, we show the previously unknown mechanisms behind the disappearance of the dental lamina, involving a combination of cell migration, cell-fate transformation, and apoptosis. Lamina regression starts with the loss of the basement membrane, allowing the epithelial cells to break away from the lamina and migrate into the surrounding mesenchyme. Cells deactivate epithelial markers (E-cadherin, cytokeratin), up-regulate Slug and MMP2, and activate mesenchymal markers (vimentin), while residual lamina cells are removed by apoptosis. The uncovering of the processes behind lamina degradation allows us to clarify the evolution of diphyodonty, and provides a mechanism for future manipulation of the number of tooth generations.
References provided by Crossref.org
Role of Cell Death in Cellular Processes During Odontogenesis
