T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition
Language English Country Czech Republic Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
22480428
DOI
10.33549/physiolres.932272
PII: 932272
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Biomarkers blood MeSH
- Diabetes Mellitus, Type 2 blood epidemiology genetics MeSH
- Adult MeSH
- Phenotype MeSH
- Gene Frequency MeSH
- Genetic Predisposition to Disease MeSH
- Diabetes, Gestational blood epidemiology genetics MeSH
- Haplotypes * MeSH
- Risk Assessment MeSH
- Polymorphism, Single Nucleotide MeSH
- Fatty Acids, Nonesterified blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Odds Ratio MeSH
- Transcription Factor 7-Like 2 Protein genetics MeSH
- Risk Factors MeSH
- Chi-Square Distribution MeSH
- Aged MeSH
- Polycystic Ovary Syndrome blood epidemiology genetics MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Biomarkers MeSH
- Fatty Acids, Nonesterified MeSH
- Transcription Factor 7-Like 2 Protein MeSH
- TCF7L2 protein, human MeSH Browser
The association of transcription factor 7-like 2 (TCF7L2) gene variants with the pathogenesis of T2D, gestational diabetes and polycystic ovary syndrome (PCOS) was examined. The study involved 1460 individuals: 347 T2D patients (D); 261 gestational diabetics (G); 147 offspring of T2D (O); 329 women with PCOS, and 376 controls (C). The SNPs: rs7901695; rs7903146; rs12255372 in the TCF7L2 gene were genotyped. Anthropometric and biochemical parameters, oGTT derived indices were assessed. In addition, free fatty acids (FFAs) were evaluated in 183 non-diabetic women. The CTT haplotype showed the strongest association with T2D with OR 1.57, p=0.0003. The frequency of the CTT/CTT haplotype was decreasing in following order: D 10.6, O 9.5, G 6.1, C 5.3 and PCOS 4.9 [%]. Among CTT carriers, significantly decreased levels of oGTT-stimulated insulin and C-peptide as well as proportions of fasting PUFAs were observed. The carriership of CTG/TCG was associated with gestational diabetes, OR 2.59, p=0.036. The association of TCF7L2 haplotypes with T2D and gestational diabetes but not with PCOS was confirmed. Novel association of TCF7L2 with FFAs composition was found.
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