Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22749068
DOI
10.1016/j.leukres.2012.05.012
PII: S0145-2126(12)00237-8
Knihovny.cz E-resources
- MeSH
- Leukemia, Myeloid, Acute diagnosis genetics mortality MeSH
- Survival Analysis MeSH
- Cytogenetic Analysis MeSH
- DNA Methyltransferase 3A MeSH
- DNA (Cytosine-5-)-Methyltransferases genetics MeSH
- Adult MeSH
- Down-Regulation genetics MeSH
- Epigenesis, Genetic physiology MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- DNA Methylation genetics MeSH
- Mutation, Missense * physiology MeSH
- Young Adult MeSH
- Prognosis MeSH
- Gene Expression Regulation, Leukemic genetics physiology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- DNA Methyltransferase 3A MeSH
- DNA (Cytosine-5-)-Methyltransferases MeSH
- DNMT3A protein, human MeSH Browser
We examined 79 acute myeloid leukemia (AML) patients for DNA methylation of 12 tumor suppressor genes (TSG) and 24 homeobox domain (Hox) genes, and additionally for mutations in DNMT3A gene. We observed lower levels of DNA methylation (P<0.0001) as well as smaller numbers of concurrently hypermethylated genes (P<0.0001) in patients with DNMT3A mutations. Our study of the impact of DNA methylation on prognosis in intermediate and high risk AML patients revealed a relation between higher DNA methylation and better patients' outcome. Lower DNA methylation was linked with higher relapse rates and an inferior overall survival.
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