Advances in patch clamp technique: towards higher quality and quantity
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
22781816
DOI
10.4149/gpb_2012_016
Knihovny.cz E-resources
- MeSH
- Action Potentials physiology MeSH
- Equipment Design trends MeSH
- Ion Channel Gating physiology MeSH
- Ion Channels metabolism MeSH
- Humans MeSH
- Membrane Potentials physiology MeSH
- Patch-Clamp Techniques instrumentation trends MeSH
- Microelectrodes trends MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Ion Channels MeSH
The patch clamp technique, developed in late 1970s, started a new period of experimental cardiac electrophysiology enabling measurement of ionic currents on isolated cardiomyocytes down to the level of single channels. Since that time, the technique has been substantially improved by development of several upgraded modifications providing so far unavailable data (e.g. action potential clamp, dynamic clamp, high-resolution scanning patch clamp), or facilitating the patch clamp technique by increasing its efficiency (planar patch clamp, automated patch clamp). The current review summarizes the leading new patch clamp based techniques used in cardiac cellular electrophysiology, their principles and prominent related papers.
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Platforms for Single-Cell Collection and Analysis
