Evaluation of topical photodynamic therapy of mammary carcinoma with an experimental gel containing liposomal hydroxyl-aluminium phthalocyanine
Language English Country Greece Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22993318
PII: 32/9/3769
Knihovny.cz E-resources
- MeSH
- Adenocarcinoma drug therapy MeSH
- Photochemotherapy methods MeSH
- Photosensitizing Agents administration & dosage chemistry MeSH
- Gels MeSH
- Indoles administration & dosage chemistry MeSH
- Coordination Complexes administration & dosage chemistry MeSH
- Humans MeSH
- Liposomes MeSH
- Mice, Nude MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Breast Neoplasms drug therapy MeSH
- Organometallic Compounds administration & dosage chemistry MeSH
- Xenograft Model Antitumor Assays MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- aluminum phthalocyanine MeSH Browser
- Photosensitizing Agents MeSH
- Gels MeSH
- Indoles MeSH
- Coordination Complexes MeSH
- Liposomes MeSH
- Organometallic Compounds MeSH
BACKGROUND: Photodynamic therapy (PDT) is a clinically-accepted approach for the therapy of many types of cancer. This study focused on the treatment of mammarian carcinoma by topical administration of hydroxyl-aluminium phthalocyanine (AlOH-PC), compared to a clinically-approved photosensitizer (Metvix, Galderma & PhotoCure ASA, Inc., Oslo, Norway). MATERIALS AND METHODS: MDA-MB 231 cells were subcutaneously injected into the right flank of athymic nude mice. Mice with grown tumours were used for in vivo efficacy studies. Different doses of liposomal AlOH-PC were applied to determine the most effective dose. In later studies, Metvix or our liposomal-AlOH-PC gel formula were used. Topical application of photosensitizers was followed by the PDT irradiation at 600-700 nm (635 nm peak). Tumour growth was measured three times weekly. RESULTS: Therapeutic studies revealed that AlOH-PC treatment led to complete tumour remission in 90% (9/10) of experimental animals, whereas usage of the commercially available Metvix only postponed the tumour growth. Moreover, usage of liposomal AlOH-PC shortened the time allowed between the application of the photosensitizer and light exposure: for Metvix, hours are usually needed, while the tested liposomal AlOH-PC showed remarkable outcomes after only 10 min. CONCLUSION: Liposomal AlOH-PC gel appears to be potentially suitable for PDT of mammarian carcinoma.
Advances in Liposome-Encapsulated Phthalocyanines for Photodynamic Therapy
