Poly(2-oxazoline)s--are they more advantageous for biomedical applications than other polymers?
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biocompatible Materials chemistry MeSH
- Hydrophobic and Hydrophilic Interactions MeSH
- Drug Carriers chemistry MeSH
- Oxazoles chemical synthesis chemistry MeSH
- Polymers chemistry MeSH
- Solutions chemistry MeSH
- Water chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Drug Carriers MeSH
- Oxazoles MeSH
- poly(2-oxazoline) MeSH Browser
- Polymers MeSH
- Solutions MeSH
- Water MeSH
Poly(2-alkyl-2-oxazoline)s are biocompatible polymers with polypeptide-isomeric structures that are attracting increasing interest as biomaterials for drug, gene, protein, and radionuclide delivery. They are, however, still relatively new in comparison to other classes of hydrophilic water-soluble polymers already established for such use, including poly(ethylene oxide), polyvinylpyrrolidone, and polymethacrylamides such as poly[N-(2-hydroxypropyl)methacrylamide]. This feature article critically compares the synthetic aspects and physicochemical and biological properties of poly(2-alkyl-2-oxazoline)s and these commonly studied polymers in terms of their suitability for biomedical applications.
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