Surface design of core-shell superparamagnetic iron oxide nanoparticles drives record relaxivity values in functional MRI contrast agents
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23066527
DOI
10.1039/c2cc35515a
Knihovny.cz E-resources
- MeSH
- NIH 3T3 Cells MeSH
- Contrast Media chemistry toxicity MeSH
- Magnetic Resonance Imaging methods MeSH
- Magnets chemistry toxicity MeSH
- Mice MeSH
- Surface Properties MeSH
- Drug Design * MeSH
- Ferric Compounds chemistry toxicity MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ferric oxide MeSH Browser
- Contrast Media MeSH
- Ferric Compounds MeSH
Core-shell hydrophilic superparamagnetic iron oxide (SPIO) nanoparticles, surface functionalized with either terephthalic acid or 2-amino terephthalic acid, showed large negative MRI contrast ability, validating the advantage of using low molecular weight and π-conjugated canopies for engineering functional nanostructures with superior performances.
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