Steroids and insulin resistance in pregnancy
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
23202146
DOI
10.1016/j.jsbmb.2012.11.007
PII: S0960-0760(12)00240-3
Knihovny.cz E-resources
- Keywords
- Gestational diabetes mellitus, Glycoregulation, Insulin resistance, Pregnancy, Steroids,
- MeSH
- Diabetes, Gestational metabolism MeSH
- Sex Hormone-Binding Globulin metabolism MeSH
- Adrenal Cortex Hormones physiology MeSH
- Insulin Resistance * MeSH
- Humans MeSH
- Gonadal Steroid Hormones physiology MeSH
- Pregnancy MeSH
- Vitamin D physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Sex Hormone-Binding Globulin MeSH
- Adrenal Cortex Hormones MeSH
- Gonadal Steroid Hormones MeSH
- Vitamin D MeSH
Metabolism of glucose during pregnancy reflects the equilibrium between lactogenic hormones stimulating insulin production and counterregulatory hormones inducing insulin resistance. In physiological pregnancies, insulin-mediated glucose uptake is substantially decreased and insulin secretion increased to maintain euglycemia. This common state of peripheral insulin resistance arises also due to steroid spectra changes. In this review article, we have focused on the role of steroid hormones (androgens, estrogens, gestagens, mineralocorticoids, glucocorticoids, as well as secosteroid vitamin D) in the impairment of glucose tolerance in pregnancy and in the pathogenesis of gestational diabetes mellitus. This article is part of a Special Issue entitled 'Pregnancy and Steroids'.
References provided by Crossref.org
Steroids, steroid associated substances and gestational diabetes mellitus
