Steroids and insulin resistance in pregnancy

. 2014 Jan ; 139 () : 122-9. [epub] 20121129

Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid23202146
Odkazy

PubMed 23202146
DOI 10.1016/j.jsbmb.2012.11.007
PII: S0960-0760(12)00240-3
Knihovny.cz E-zdroje

Metabolism of glucose during pregnancy reflects the equilibrium between lactogenic hormones stimulating insulin production and counterregulatory hormones inducing insulin resistance. In physiological pregnancies, insulin-mediated glucose uptake is substantially decreased and insulin secretion increased to maintain euglycemia. This common state of peripheral insulin resistance arises also due to steroid spectra changes. In this review article, we have focused on the role of steroid hormones (androgens, estrogens, gestagens, mineralocorticoids, glucocorticoids, as well as secosteroid vitamin D) in the impairment of glucose tolerance in pregnancy and in the pathogenesis of gestational diabetes mellitus. This article is part of a Special Issue entitled 'Pregnancy and Steroids'.

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Steroids, steroid associated substances and gestational diabetes mellitus

. 2021 Dec 30 ; 70 (Suppl4) : S617-S634.

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