Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- alergie genetika imunologie veterinární MeSH
- Ceratopogonidae imunologie patogenita MeSH
- dermatitida genetika veterinární MeSH
- hlavní histokompatibilní komplex genetika MeSH
- koně genetika imunologie MeSH
- kousnutí a bodnutí hmyzem genetika imunologie MeSH
- Simuliidae imunologie patogenita MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Island MeSH
Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of insects. IBH is a multifactorial disease with contribution of genetic and environmental factors. Candidate gene association analysis of IBH was performed in a group of 89 Icelandic horses all born in Iceland and imported to Europe. Horses were classified in IBH-affected and non-affected based on clinical signs and history of recurrent dermatitis, and on the results of an in vitro sulfidoleukotriene (sLT)-release assay with Culicoides nubeculosus and Simulium vittatum extract. Different genetic markers were tested for association with IBH by the Fisher's exact test. The effect of the major histocompatibility complex (MHC) gene region was studied by genotyping five microsatellites spanning the MHC region (COR112, COR113, COR114, UM011 and UMN-JH34-2), and exon 2 polymorphisms of the class II Eqca-DRA gene. Associations with Eqca-DRA and COR113 were identified (p < 0.05). In addition, a panel of 20 single nucleotide polymorphisms (SNPs) in 17 candidate allergy-related genes was tested. During the initial screen, no marker from the panel was significantly (p < 0.05) associated with IBH. Five SNPs associated with IBH at p < 0.10 were therefore used for analysis of combined genotypes. Out of them, SNPs located in the genes coding for the CD14 receptor (CD14), interleukin 23 receptor (IL23R), thymic stromal lymphopoietin (TSLP) and transforming growth factor beta 3 (TGFB3) molecules were associated with IBH as parts of complex genotypes. These results are supported by similar associations and by expression data from different horse populations and from human studies.
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Vet J. 2008 Sep;177(3):334-44 PubMed
Vet Immunol Immunopathol. 2008 Mar 15;122(1-2):65-75 PubMed
J Immunol. 2003 Sep 15;171(6):3262-9 PubMed
Anim Genet. 2013 Feb;44(1):44-52 PubMed
Immunol Rev. 2011 Jul;242(1):233-46 PubMed
Int Arch Allergy Immunol. 2007;144(4):325-37 PubMed
Equine Vet J. 2006 Jan;38(1):40-6 PubMed
Hum Genet. 2007 Sep;122(2):201-6 PubMed
Animal. 2008 Mar;2(3):360-5 PubMed
Vet Immunol Immunopathol. 2011 Mar 15;140(1-2):63-74 PubMed
Immunogenetics. 2009 Jul;61(7):513-27 PubMed
Anim Genet. 2010 Dec;41 Suppl 2:150-3 PubMed
Immunogenetics. 2012 Mar;64(3):201-8 PubMed
Acta Vet Scand. 2006 May 26;48:3 PubMed
Int Arch Allergy Immunol. 2007;143(3):177-84 PubMed
Cell. 1986 Aug 15;46(4):583-9 PubMed
Vet Immunol Immunopathol. 2012 Jun 30;147(3-4):113-26 PubMed
Cell Biol Int. 1995 May;19(5):357-71 PubMed
Vet Immunol Immunopathol. 2010 Dec 1;138(3):193-7 PubMed
Genome Res. 2009 May;19(5):711-22 PubMed
Immunogenetics. 1996;43(5):315-7 PubMed
Equine Vet J. 1992 Mar;24(2):113-7 PubMed
Anim Genet. 1994 Jun;25 Suppl 1:75-80 PubMed
J Anim Sci. 2011 May;89(5):1286-93 PubMed
Cell Res. 2010 Jan;20(1):62-71 PubMed
PLoS One. 2010 Nov 12;5(11):e13894 PubMed
Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):351-61 PubMed
J Allergy Clin Immunol. 2005 May;115(5):1056-62 PubMed
J Allergy Clin Immunol. 2001 Aug;108(2):281-4 PubMed
J Leukoc Biol. 2012 Jun;91(6):877-86 PubMed
World J Gastroenterol. 2010 Jan 14;16(2):176-83 PubMed
J Mol Med (Berl). 2005 Sep;83(9):682-92 PubMed
Brief Bioinform. 2008 Jan;9(1):1-13 PubMed
