Polymorphism and selection in the major histocompatibility complex DRA and DQA genes in the family Equidae
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
19557406
DOI
10.1007/s00251-009-0380-0
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- DNA primery genetika MeSH
- DNA genetika MeSH
- druhová specificita MeSH
- Equidae klasifikace genetika imunologie MeSH
- fylogeneze MeSH
- genetická variace MeSH
- hlavní histokompatibilní komplex * MeSH
- imunogenetické jevy MeSH
- koně genetika imunologie MeSH
- molekulární evoluce MeSH
- molekulární sekvence - údaje MeSH
- polymorfismus genetický * MeSH
- polymorfismus konformace jednovláknové DNA MeSH
- sekvence nukleotidů MeSH
- sekvenční homologie nukleových kyselin MeSH
- selekce (genetika) * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- DNA primery MeSH
- DNA MeSH
The major histocompatibility complex genes coding for antigen binding and presenting molecules are the most polymorphic genes in the vertebrate genome. We studied the DRA and DQA gene polymorphism of the family Equidae. In addition to 11 previously reported DRA and 24 DQA alleles, six new DRA sequences and 13 new DQA alleles were identified in the genus Equus. Phylogenetic analysis of both DRA and DQA sequences provided evidence for trans-species polymorphism in the family Equidae. The phylogenetic trees differed from species relationships defined by standard taxonomy of Equidae and from trees based on mitochondrial or neutral gene sequence data. Analysis of selection showed differences between the less variable DRA and more variable DQA genes. DRA alleles were more often shared by more species. The DQA sequences analysed showed strong amongst-species positive selection; the selected amino acid positions mostly corresponded to selected positions in rodent and human DQA genes.
Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?
Natural killer cell receptor genes in the family Equidae: not only Ly49
