Can repetitive transcranial magnetic stimulation be considered effective treatment option for negative symptoms of schizophrenia?
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, metaanalýza, práce podpořená grantem, přehledy
- MeSH
- adherence pacienta MeSH
- dvojitá slepá metoda MeSH
- klinické zkoušky jako téma MeSH
- lidé MeSH
- mozková kůra anatomie a histologie MeSH
- randomizované kontrolované studie jako téma MeSH
- schizofrenie (psychologie) MeSH
- schizofrenie terapie MeSH
- transkraniální magnetická stimulace metody MeSH
- věkové faktory MeSH
- výsledek terapie MeSH
- výzkumný projekt MeSH
- vztah dávky záření a odpovědi MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
OBJECTIVE: Despite the development of second-generation antipsychotic drugs, treatment-resistant symptoms still represent a serious problem in schizophrenia. The aim of the present article was to review studies with repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia and draw conclusions for clinical decision making. METHOD: Literature for this review was identified by searching MEDLINE and ISI Web of Science up to the year 2011. RESULTS: Five open studies, 13 sham-controlled studies, and 2 meta-analysis and 2 review articles were included in the present paper. The effect size of the high frequency repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex in the treatment of negative symptoms of schizophrenia is thought to be mild to moderate (Cohen d = 0.43-0.68). CONCLUSION: Despite the promising results of some rTMS studies, the potential of rTMS for the treatment of negative symptoms is currently relatively unclear. Large clinical studies are therefore needed, especially large multicentric studies such as depression rTMS studies.
Citace poskytuje Crossref.org
