The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23338609
DOI
10.1158/0008-5472.can-12-1752
PII: 0008-5472.CAN-12-1752
Knihovny.cz E-resources
- MeSH
- B-Lymphocytes pathology MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell metabolism pathology MeSH
- Humans MeSH
- Membrane Proteins metabolism MeSH
- Mice MeSH
- Cell Movement * MeSH
- Cell Polarity * MeSH
- Wnt Signaling Pathway MeSH
- Signal Transduction MeSH
- Transplantation, Heterologous MeSH
- Up-Regulation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Membrane Proteins MeSH
The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-ε are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment.
References provided by Crossref.org
The role of prickle proteins in vertebrate development and pathology
Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?
Targeting Casein Kinase 1 (CK1) in Hematological Cancers
Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer
Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas
WNT5A: a motility-promoting factor in Hodgkin lymphoma
