Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- artroplastika MeSH
- infekce spojené s protézou genetika MeSH
- infekce MeSH
- jednonukleotidový polymorfismus MeSH
- klouby chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- protézy a implantáty škodlivé účinky MeSH
- senioři MeSH
- stafylokokové infekce genetika MeSH
- Staphylococcus MeSH
- toll-like receptor 2 genetika MeSH
- toll-like receptor 4 genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- TLR2 protein, human MeSH Prohlížeč
- TLR4 protein, human MeSH Prohlížeč
- toll-like receptor 2 MeSH
- toll-like receptor 4 MeSH
OBJECTIVE AND DESIGN: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI. SUBJECTS AND METHODS: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphisms of the genes encoding for TLR2 (TLR2 R753Q, rs5743708) and TLR4 (TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by "TaqMan" assay. RESULTS: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/healthy individuals. CONCLUSION: Our data suggest that structural genetic variants of the receptors TLR2 and TLR4 do not substantially affect the risk of prosthetic joint infection.
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