The significance of stereotyped B-cell receptors in chronic lymphocytic leukemia
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
23561471
DOI
10.1016/j.hoc.2012.12.001
PII: S0889-8588(12)00245-6
Knihovny.cz E-resources
- MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell classification genetics immunology MeSH
- Immunoglobulins classification immunology metabolism MeSH
- Humans MeSH
- Receptors, Antigen, B-Cell genetics immunology metabolism MeSH
- Antibody Diversity immunology MeSH
- Somatic Hypermutation, Immunoglobulin MeSH
- Immunoglobulin Heavy Chains genetics immunology MeSH
- Immunoglobulin Variable Region genetics immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Immunoglobulins MeSH
- Receptors, Antigen, B-Cell MeSH
- Immunoglobulin Heavy Chains MeSH
- Immunoglobulin Variable Region MeSH
Roughly 30% of patients with chronic lymphocytic leukemia (CLL) carry immunoglobulin receptors with highly similar primary sequences. Highly similar, quasi-identical immunoglobulins are termed stereotyped. Patients with CLL can be assigned to different subsets expressing different types of stereotyped immunoglobulin receptors. Reliable identification of stereotypy may assist in the molecular classification of CLL and thus better-guided, compartmentalized research. In several major subsets, stereotypy extends from shared primary sequences to shared clinicobiological features and outcome. Reliable identification of stereotypy in CLL may pave the way for tailored treatment strategies applicable to each major stereotyped subset.
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