A new way of solid dosage form samples preparation for SEM and FTIR using microtome
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Chemistry, Pharmaceutical methods MeSH
- Dosage Forms MeSH
- Microscopy, Electron, Scanning methods MeSH
- Excipients chemistry MeSH
- Spectroscopy, Fourier Transform Infrared methods MeSH
- Tablets chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dosage Forms MeSH
- Excipients MeSH
- Tablets MeSH
Rapid and correct production of generic solid dosage forms requires a large amount of analytical data and conclusions. Modern analytical techniques have a good resolution and accuracy and allow obtaining a lot of information about the original product. Scanning electron microscopy (SEM) is used for observation and assessing individual layers, core and surface of solid dosage forms. Fourier transform infrared (FTIR) spectroscopy mapping allows determining the distribution and characterization of individual components in a solid dosage form. However, the samples prepared by common way, using scalpel or tablet splitter, are not good enough. It was the reason for development of a new and better method of sample preparation, which uses microtome. Well-prepared samples analyzed by SEM and FTIR mapping allow to determine a solid dosage form formulation, excipient content and distribution of excipient and active pharmaceutical ingredient.
References provided by Crossref.org
Hot-stage microscopy for determination of API particles in a formulated tablet
