A new way of solid dosage form samples preparation for SEM and FTIR using microtome
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- farmaceutická chemie metody MeSH
- lékové formy MeSH
- mikroskopie elektronová rastrovací metody MeSH
- pomocné látky chemie MeSH
- spektroskopie infračervená s Fourierovou transformací metody MeSH
- tablety chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- lékové formy MeSH
- pomocné látky MeSH
- tablety MeSH
Rapid and correct production of generic solid dosage forms requires a large amount of analytical data and conclusions. Modern analytical techniques have a good resolution and accuracy and allow obtaining a lot of information about the original product. Scanning electron microscopy (SEM) is used for observation and assessing individual layers, core and surface of solid dosage forms. Fourier transform infrared (FTIR) spectroscopy mapping allows determining the distribution and characterization of individual components in a solid dosage form. However, the samples prepared by common way, using scalpel or tablet splitter, are not good enough. It was the reason for development of a new and better method of sample preparation, which uses microtome. Well-prepared samples analyzed by SEM and FTIR mapping allow to determine a solid dosage form formulation, excipient content and distribution of excipient and active pharmaceutical ingredient.
Citace poskytuje Crossref.org
Hot-stage microscopy for determination of API particles in a formulated tablet
