Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy
Language English Country Great Britain, England Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
23648586
DOI
10.1016/j.exger.2013.04.012
PII: S0531-5565(13)00119-8
Knihovny.cz E-resources
- Keywords
- Auditory cortex, EP, GABA, Glutamate, Lactate, MP, MR spectroscopy, N-acetylaspartate, NAA, Presbycusis, VOI, YC, elderly subjects with expressed presbycusis, elderly subjects with mild presbycusis, volume of interest, young subjects with physiologic hearing,
- MeSH
- Audiometry, Pure-Tone MeSH
- Adult MeSH
- Glutamates metabolism MeSH
- Aspartic Acid analogs & derivatives metabolism MeSH
- Lactates metabolism MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy * MeSH
- Presbycusis metabolism MeSH
- Aged MeSH
- Auditory Cortex metabolism MeSH
- Aging metabolism MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Glutamates MeSH
- Aspartic Acid MeSH
- Lactates MeSH
- N-acetylaspartate MeSH Browser
In humans, aging is accompanied by the deterioration of the hearing function--presbycusis. The major etiology for presbycusis is the loss of hair cells in the inner ear; less well known are changes in the central auditory system. Therefore, we used 1H magnetic resonance spectroscopy at 3T tomograph to examine metabolite levels in the auditory cortex of three groups of subjects: young healthy subjects less than 30 years old and subjects older than 65 years either with mild presbycusis corresponding to their age or with expressed presbycusis. Hearing function in all subjects was examined by pure tone audiometry (125-16,000 Hz). Significant differences were found in the concentrations of glutamate and N-acetylaspartate, with lower levels in aged subjects. Lactate was particularly increased in subjects with expressed presbycusis. Significant differences were not found in other metabolites, including GABA, between young and elderly subjects. The results demonstrate that the age-related changes of the inner ear are accompanied by a decrease in the excitatory neurotransmitter glutamate as well as a lactate increase in the auditory cortex that is more expressed in elderly subjects with large hearing threshold shifts.
References provided by Crossref.org
Functional Age-Related Changes Within the Human Auditory System Studied by Audiometric Examination
