Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
23648586
DOI
10.1016/j.exger.2013.04.012
PII: S0531-5565(13)00119-8
Knihovny.cz E-zdroje
- Klíčová slova
- Auditory cortex, EP, GABA, Glutamate, Lactate, MP, MR spectroscopy, N-acetylaspartate, NAA, Presbycusis, VOI, YC, elderly subjects with expressed presbycusis, elderly subjects with mild presbycusis, volume of interest, young subjects with physiologic hearing,
- MeSH
- audiometrie čistými tóny MeSH
- dospělí MeSH
- glutamáty metabolismus MeSH
- kyselina asparagová analogy a deriváty metabolismus MeSH
- laktáty metabolismus MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie * MeSH
- presbyakuze metabolismus MeSH
- senioři MeSH
- sluchové korové centrum metabolismus MeSH
- stárnutí metabolismus MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- glutamáty MeSH
- kyselina asparagová MeSH
- laktáty MeSH
- N-acetylaspartate MeSH Prohlížeč
In humans, aging is accompanied by the deterioration of the hearing function--presbycusis. The major etiology for presbycusis is the loss of hair cells in the inner ear; less well known are changes in the central auditory system. Therefore, we used 1H magnetic resonance spectroscopy at 3T tomograph to examine metabolite levels in the auditory cortex of three groups of subjects: young healthy subjects less than 30 years old and subjects older than 65 years either with mild presbycusis corresponding to their age or with expressed presbycusis. Hearing function in all subjects was examined by pure tone audiometry (125-16,000 Hz). Significant differences were found in the concentrations of glutamate and N-acetylaspartate, with lower levels in aged subjects. Lactate was particularly increased in subjects with expressed presbycusis. Significant differences were not found in other metabolites, including GABA, between young and elderly subjects. The results demonstrate that the age-related changes of the inner ear are accompanied by a decrease in the excitatory neurotransmitter glutamate as well as a lactate increase in the auditory cortex that is more expressed in elderly subjects with large hearing threshold shifts.
Citace poskytuje Crossref.org
Functional Age-Related Changes Within the Human Auditory System Studied by Audiometric Examination
