Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF-19 and FGF-21 in morbidly obese subjects
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23670968
DOI
10.1002/oby.20208
Knihovny.cz E-zdroje
- MeSH
- adiponektin krev MeSH
- amylin krev MeSH
- C-reaktivní protein metabolismus MeSH
- dospělí MeSH
- fibroblastové růstové faktory krev MeSH
- gastrektomie metody MeSH
- ghrelin krev MeSH
- glukagonu podobný peptid 1 krev MeSH
- hmotnostní úbytek MeSH
- index tělesné hmotnosti MeSH
- inzulin krev MeSH
- inzulinová rezistence MeSH
- leptin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- messenger RNA metabolismus MeSH
- morbidní obezita krev chirurgie MeSH
- obvod pasu MeSH
- pankreatický polypeptid krev MeSH
- peptid YY krev MeSH
- podkožní tuk metabolismus MeSH
- prospektivní studie MeSH
- resistin krev MeSH
- žaludeční inhibiční polypeptid krev MeSH
- žlučové kyseliny a soli krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adiponektin MeSH
- amylin MeSH
- C-reaktivní protein MeSH
- FGF19 protein, human MeSH Prohlížeč
- fibroblast growth factor 21 MeSH Prohlížeč
- fibroblastové růstové faktory MeSH
- ghrelin MeSH
- glukagonu podobný peptid 1 MeSH
- inzulin MeSH
- leptin MeSH
- messenger RNA MeSH
- pankreatický polypeptid MeSH
- peptid YY MeSH
- resistin MeSH
- žaludeční inhibiční polypeptid MeSH
- žlučové kyseliny a soli MeSH
OBJECTIVE: Fibroblast growth factor (FGF)-19 and FGF-21 are novel metabolic regulators that improve insulin resistance and obesity in rodents. The aim of the study was to assess the effects of laparoscopic sleeve gastrectomy (LSG) on serum concentrations of FGF-19 and FGF-21 along with circulating bile acids and other relevant hormonal and biochemical parameters. DESIGN AND METHODS: Seventeen females with obesity undergoing LSG and 15 lean healthy females were included into the study. Anthropometric and biochemical parameters, serum concentrations of FGF-19 and -21, insulin, adiponectin, leptin, C-reactive protein, resistin, amylin (total), ghrelin (active), glucagon-like peptide 1 (GLP-1, active), glucose-dependent insulinotropic peptide (GIP, total), peptide YY (PYY, total), pancreatic polypeptide (PP), and bile acids, and mRNA expression of selected adipokines and inflammatory markers in bioptic samples of subcutaneous fat were assessed at baseline and 6, 12, and 24 months after LSG. RESULTS: LSG markedly decreased body weight, BMI, waist circumference, and insulin levels and improved systemic inflammation and lipid levels. FGF-19 concentrations increased and FGF-21 concentrations decreased after LSG along with increased adiponectin and decreased leptin, amylin, and ghrelin levels. GLP-1, GIP, PP, and circulating bile acids were not affected by LSG. PYY decreased significantly 24 months after surgery only. mRNA expression analysis in subcutaneous fat showed markedly reduced proinflammatory state. CONCLUSIONS: Our results indicate that increased FGF-19 and decreased ghrelin concentrations could have partially contributed to the improvement of systemic inflammation and some metabolic parameters after LSG, while changes of FGF-21 are rather secondary because of weight loss.
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