Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF-19 and FGF-21 in morbidly obese subjects
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23670968
DOI
10.1002/oby.20208
Knihovny.cz E-resources
- MeSH
- Adiponectin blood MeSH
- Islet Amyloid Polypeptide blood MeSH
- C-Reactive Protein metabolism MeSH
- Adult MeSH
- Fibroblast Growth Factors blood MeSH
- Gastrectomy methods MeSH
- Ghrelin blood MeSH
- Glucagon-Like Peptide 1 blood MeSH
- Weight Loss MeSH
- Body Mass Index MeSH
- Insulin blood MeSH
- Insulin Resistance MeSH
- Leptin blood MeSH
- Middle Aged MeSH
- Humans MeSH
- RNA, Messenger metabolism MeSH
- Obesity, Morbid blood surgery MeSH
- Waist Circumference MeSH
- Pancreatic Polypeptide blood MeSH
- Peptide YY blood MeSH
- Subcutaneous Fat metabolism MeSH
- Prospective Studies MeSH
- Resistin blood MeSH
- Gastric Inhibitory Polypeptide blood MeSH
- Bile Acids and Salts blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adiponectin MeSH
- Islet Amyloid Polypeptide MeSH
- C-Reactive Protein MeSH
- FGF19 protein, human MeSH Browser
- fibroblast growth factor 21 MeSH Browser
- Fibroblast Growth Factors MeSH
- Ghrelin MeSH
- Glucagon-Like Peptide 1 MeSH
- Insulin MeSH
- Leptin MeSH
- RNA, Messenger MeSH
- Pancreatic Polypeptide MeSH
- Peptide YY MeSH
- Resistin MeSH
- Gastric Inhibitory Polypeptide MeSH
- Bile Acids and Salts MeSH
OBJECTIVE: Fibroblast growth factor (FGF)-19 and FGF-21 are novel metabolic regulators that improve insulin resistance and obesity in rodents. The aim of the study was to assess the effects of laparoscopic sleeve gastrectomy (LSG) on serum concentrations of FGF-19 and FGF-21 along with circulating bile acids and other relevant hormonal and biochemical parameters. DESIGN AND METHODS: Seventeen females with obesity undergoing LSG and 15 lean healthy females were included into the study. Anthropometric and biochemical parameters, serum concentrations of FGF-19 and -21, insulin, adiponectin, leptin, C-reactive protein, resistin, amylin (total), ghrelin (active), glucagon-like peptide 1 (GLP-1, active), glucose-dependent insulinotropic peptide (GIP, total), peptide YY (PYY, total), pancreatic polypeptide (PP), and bile acids, and mRNA expression of selected adipokines and inflammatory markers in bioptic samples of subcutaneous fat were assessed at baseline and 6, 12, and 24 months after LSG. RESULTS: LSG markedly decreased body weight, BMI, waist circumference, and insulin levels and improved systemic inflammation and lipid levels. FGF-19 concentrations increased and FGF-21 concentrations decreased after LSG along with increased adiponectin and decreased leptin, amylin, and ghrelin levels. GLP-1, GIP, PP, and circulating bile acids were not affected by LSG. PYY decreased significantly 24 months after surgery only. mRNA expression analysis in subcutaneous fat showed markedly reduced proinflammatory state. CONCLUSIONS: Our results indicate that increased FGF-19 and decreased ghrelin concentrations could have partially contributed to the improvement of systemic inflammation and some metabolic parameters after LSG, while changes of FGF-21 are rather secondary because of weight loss.
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