The influence of quarternary salt on hyaluronan conformation and particle size in solution
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23987445
DOI
10.1016/j.carbpol.2013.06.057
PII: S0144-8617(13)00653-X
Knihovny.cz E-resources
- Keywords
- Critical micellar concentration, Dynamic light scattering, Hyaluronan, Hyaluronan conformation, Hyaluronan hydrophobic interactions, Quarternary salts,
- MeSH
- Benzalkonium Compounds chemistry MeSH
- Carbohydrate Conformation MeSH
- Hyaluronic Acid chemistry MeSH
- Micelles MeSH
- Surface Tension MeSH
- Solutions MeSH
- Salts chemistry MeSH
- Particle Size * MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Benzalkonium Compounds MeSH
- Hyaluronic Acid MeSH
- Micelles MeSH
- Solutions MeSH
- Salts MeSH
Interaction of hyaluronan (NaHy) with the quaternary salt, benzalkonium chloride (BAC), was studied. Based on the DLS experiments, viscometry and surface tension measurements executed on hyaluronan samples with two molecular weights of Mw=1.8 MDa and Mw=0.35 MDa, the hypothesis was proposed suggesting that at certain BAC concentrations, hyaluronan can form aggregates, which lead to increase of the polymer coil size measured as z-average diameter. Moreover, it was confirmed that within the whole range of BAC concentrations, repeated variations in size and conformations of polymer coils occur, being connected with the critical micellar concentration of BAC and with hydrophobic interactions of non-polar segments of BAC with hyaluronan hydrophobic domains. Tensiometry, DLS and viscometry data support the assumption that variations of thermodynamical "favourability" of BAC-BAC or NaHy-BAC interactions take place in hyaluronan solutions, based on the BAC concentration.
References provided by Crossref.org
Electrospinning of Hyaluronan Using Polymer Coelectrospinning and Intermediate Solvent
