The influence of quarternary salt on hyaluronan conformation and particle size in solution
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23987445
DOI
10.1016/j.carbpol.2013.06.057
PII: S0144-8617(13)00653-X
Knihovny.cz E-zdroje
- Klíčová slova
- Critical micellar concentration, Dynamic light scattering, Hyaluronan, Hyaluronan conformation, Hyaluronan hydrophobic interactions, Quarternary salts,
- MeSH
- benzalkoniové sloučeniny chemie MeSH
- konformace sacharidů MeSH
- kyselina hyaluronová chemie MeSH
- micely MeSH
- povrchové napětí MeSH
- roztoky MeSH
- soli chemie MeSH
- velikost částic * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- benzalkoniové sloučeniny MeSH
- kyselina hyaluronová MeSH
- micely MeSH
- roztoky MeSH
- soli MeSH
Interaction of hyaluronan (NaHy) with the quaternary salt, benzalkonium chloride (BAC), was studied. Based on the DLS experiments, viscometry and surface tension measurements executed on hyaluronan samples with two molecular weights of Mw=1.8 MDa and Mw=0.35 MDa, the hypothesis was proposed suggesting that at certain BAC concentrations, hyaluronan can form aggregates, which lead to increase of the polymer coil size measured as z-average diameter. Moreover, it was confirmed that within the whole range of BAC concentrations, repeated variations in size and conformations of polymer coils occur, being connected with the critical micellar concentration of BAC and with hydrophobic interactions of non-polar segments of BAC with hyaluronan hydrophobic domains. Tensiometry, DLS and viscometry data support the assumption that variations of thermodynamical "favourability" of BAC-BAC or NaHy-BAC interactions take place in hyaluronan solutions, based on the BAC concentration.
Citace poskytuje Crossref.org
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