While there is good evidence for altered resting-state networks, particularly the default mode network (DMN), in both Alzheimer's disease (AD) and amnestic mild cognitive impairment preceding AD, there are rather conflicting data on changes in the DMN in Parkinson's disease (PD) and PD with cognitive impairment. This paper will focus on DMN study results, particularly in PD, as assessed by functional MRI.

Applied Neuroscience Research Group Central European Institute of Technology Masaryk University and 1st Department of Neurology School of Medicine Masaryk University and St Anne's Hospital Brno Czech Republic

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Disruption of resting functional connectivity in Alzheimer's patients and at-risk subjects