Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24118828
DOI
10.1111/brv.12059
Knihovny.cz E-resources
- Keywords
- complex diseases, genetic influence, human, hypothesis-driven approach, hypothesis-independent manner, immunoglobulin E, mouse, multiple interacting genes, mutation in a single gene, serum level,
- MeSH
- Hypersensitivity genetics metabolism MeSH
- Species Specificity MeSH
- Immunoglobulin E genetics immunology metabolism MeSH
- Humans MeSH
- Mice MeSH
- Gene Expression Regulation immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Immunoglobulin E MeSH
Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody.
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