Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
24118828
DOI
10.1111/brv.12059
Knihovny.cz E-zdroje
- Klíčová slova
- complex diseases, genetic influence, human, hypothesis-driven approach, hypothesis-independent manner, immunoglobulin E, mouse, multiple interacting genes, mutation in a single gene, serum level,
- MeSH
- alergie genetika metabolismus MeSH
- druhová specificita MeSH
- imunoglobulin E genetika imunologie metabolismus MeSH
- lidé MeSH
- myši MeSH
- regulace genové exprese imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- imunoglobulin E MeSH
Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody.
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