Reactive hyperaemia index as a marker of endothelial dysfunction in children with Crohn's disease is significantly lower than healthy controls
Language English Country Norway Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24127842
DOI
10.1111/apa.12467
Knihovny.cz E-resources
- Keywords
- Asymmetric dimethylarginine, Crohn's disease, children, endothelial dysfunction reactive hyperaemia index,
- MeSH
- Atherosclerosis MeSH
- Biomarkers blood MeSH
- Endothelium, Vascular physiopathology MeSH
- Crohn Disease blood complications physiopathology MeSH
- Hyperemia complications physiopathology MeSH
- Humans MeSH
- Adolescent MeSH
- Case-Control Studies MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
AIM: Patients with inflammatory bowel disease (IBD) are prone to cardiovascular disorders, although there is little research to support this assertion, and other data are controversial in children. We aimed to determine the extent of premature atherosclerosis in Crohn's disease (CD) by measuring reactive hyperaemia index (RHI) as a functional marker of endothelial dysfunction (ED). METHODS: Twenty-one patients with CD and twelve healthy matched subjects were enrolled in the study. Diagnosis was based on the standard clinical, endoscopic and histological criteria, including the Paediatric Crohn's disease Activity Index. ED was assessed using the plethysmographic RHI, combined with specific biochemical markers of ED. RESULT: RHI values were significantly lower in the patients with CD than the controls (p < 0.05). E-selectin (p < 0.05), asymmetric dimethylarginine (p < 0.01) and high-sensitive CRP (p < 0.05), but not vascular cells adhesive molecule-1 values, were significantly increased in the CD subjects compared with the control group. CONCLUSION: Significantly decreased RHI and elevated plasma levels of specific biochemical parameters seems to be related to systemic inflammation and ED in children with CD. Our results support the hypothesis regarding RHI and ED in paediatric CD. This combined method assessment might be a useful tool for detection of ED and stratification of cardiovascular risk in patients with CD.
References provided by Crossref.org
Bronchial Asthma as a Cardiovascular Risk Factor: A Prospective Observational Study
