Effect of prenatal methamphetamine exposure and challenge dose of the same drug in adulthood on epileptiform activity induced by electrical stimulation in female rats
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24215975
DOI
10.1016/j.neuroscience.2013.10.069
PII: S0306-4522(13)00922-6
Knihovny.cz E-resources
- Keywords
- ADs, ANOVA, EEG, GD, M/D, MA, N-Methyl-D-Aspartate, NMDA, P/E, PD, S.E.M., SADs, WDS, afterdischarges, analysis of variance, electrical stimulation, electroencephalography, gestational day, metestrus/diestrus, methamphetamine, postnatal day, proestrus/estrus, spontaneous ADs, standard error of the mean, wet-dog-shakes,
- MeSH
- Electric Stimulation adverse effects MeSH
- Electroencephalography MeSH
- Epilepsy drug therapy etiology MeSH
- Estrous Cycle MeSH
- Head Movements drug effects physiology MeSH
- Rats MeSH
- Methamphetamine pharmacology therapeutic use MeSH
- Disease Models, Animal MeSH
- Statistics, Nonparametric MeSH
- Animals, Newborn MeSH
- Rats, Wistar MeSH
- Central Nervous System Stimulants pharmacology MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects chemically induced physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Methamphetamine MeSH
- Central Nervous System Stimulants MeSH
Our previous study demonstrated that chronic prenatal methamphetamine (MA) exposure and a single dose of MA in adulthood decrease focally induced epileptiform activity in adult male rats. As seizures are known to be dependent on sex and female estrous cycle, the goal of the present study was to examine the combined effect of prenatal MA exposure (5mg/kg) and the MA challenge dose (1mg/kg) in adulthood on electroencephalography (EEG) recordings and consequences of brain stimulation in freely moving adult female rats with respect to the estrous cycle. Overall, 12 groups of adult female rats were tested: prenatally MA-exposed, prenatally saline-exposed and rats without prenatal injections, each of these groups was either postnatally challenged with MA or with saline injection (MA-MA, MA-S; S-MA, S-S; C-MA, C-S) and further divided according to the stage of the estrous cycle to metestrus/diestrus (M/D) or proestrus/estrus (P/E). Seizures were induced by repetitive electrical stimulation (15s/8Hz) of sensorimotor cortex. Stimulation threshold, duration of afterdischarges (ADs), and presence and duration of spontaneous ADs (SADs) were evaluated. Additionally, behavior associated with stimulation and ADs, and occurrence of wet-dog-shakes (WDS) were analyzed. The present study demonstrates that the prenatal MA exposure decreased the seizure threshold in females in M/D, but not in females in P/E. In addition, prenatally MA-exposed M/D females injected with saline in adulthood had increased the duration of ADs as well as SADs. The challenge dose of MA also decreased the seizure threshold. Moreover, prenatal as well as adult MA administration decreased the number and occurrence of WDS, respectively. Thus, the present study demonstrates that the effect of prenatal MA exposure and challenge dose of the same drug on focally induced epileptiform activity in adult female rats depends on the estrous cycle.
References provided by Crossref.org
Influence of Prenatal Methamphetamine Abuse on the Brain
Prenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes
