Life-threatening course of pemphigus vulgaris complicated by sepsis caused by azathioprine-induced bone marrow suppression, successfully managed with combination therapy
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article
PubMed
24283408
DOI
10.1111/dth.12114
Knihovny.cz E-resources
- Keywords
- own experience, resistant form of pemphigus vulgaris, therapeutic possibilities,
- MeSH
- Anti-Bacterial Agents therapeutic use MeSH
- Antifungal Agents therapeutic use MeSH
- Azathioprine adverse effects MeSH
- Biopsy MeSH
- Time Factors MeSH
- Adrenal Cortex Hormones administration & dosage MeSH
- Immunosuppressive Agents adverse effects MeSH
- Immunoglobulins, Intravenous therapeutic use MeSH
- Drug Therapy, Combination MeSH
- Skin drug effects pathology MeSH
- Leukopenia chemically induced diagnosis therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Pemphigus diagnosis drug therapy MeSH
- Pulse Therapy, Drug MeSH
- Recurrence MeSH
- Sepsis chemically induced diagnosis therapy MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Antifungal Agents MeSH
- Azathioprine MeSH
- Adrenal Cortex Hormones MeSH
- Immunosuppressive Agents MeSH
- Immunoglobulins, Intravenous MeSH
Severe forms of pemphigus vulgaris (PV) that are resistant to standard treatment present a life-threatening disease with a mortality of 5-10%. The treatment is usually individualized. The most popular procedures used today include intravenous applications of immunoglobulins and rituximab. Currently the common use of pulse corticosteroids, often in first-line treatment, is being neglected. This particular case documented the severity of the disease and also the need for combined and comprehensive care, in which corticosteroid pulse therapy still plays an important role.
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