AIMS: To evaluate the rate of clinical events and bleeding risk according to age in patients undergoing percutaneous coronary intervention (PCI) with a new-generation drug-eluting stent (DES) enrolled in the RESOLUTE Global Clinical Program. METHODS: This study represents a pooled analysis of five trials included in the RESOLUTE program including 5,130 patients, of whom 1,675 (32.6%) were ≥70 years old (elderly patients). RESULTS: After adjusting for confounders, age ≥70 years was a significant predictor of high mortality at 30 days (0.6 vs. 0.1%, P = 0.017) and 2 years (7.2 vs. 2%, P < 0.001). No differences were seen with respect to acute myocardial infarction (MI) or target lesion and vessel revascularization rates between young and elderly patients. Bleeding rates were higher in the elderly throughout follow-up. In the elderly, 7 of the 27 (26%) patients with bleeding episodes died, with a median time between bleeding episode to death of 21 days. In the younger population, 1 patient of 17 with a bleeding episode died (400 days later). CONCLUSIONS: Elderly patients undergoing PCI with a new-generation DES have increased mortality and bleeding risk, with similar rates of acute MI and repeat revascularization. Bleeding risk was higher in the elderly and strongly related to death. Target lesion failure rates were not significantly different between the two age groups, suggesting that the Resolute zotarolimus-eluting stent (R-ZES) is effective for patients younger and older than 70 years of age. R-ZES may be recommended for elderly patients when PCI with a DES is identified as a suitable option.

Cardiology Department Royal Victoria Hospital Belfast Northern Ireland United Kingdom

Cardiology Department the 3rd Faculty of Medicine Charles University and University Hospital Royal Vineyards Prague Czech Republic

Department of Cardiac Surgery and Department of Images Instituto Cardiovascular de Buenos Aires Buenos Aires Argentina

Department of Cardiology and Catheterization Laboratories Shonan Kamakura General Hospital Kamakura City Japan

Department of Cardiology Heart Centre at the Isar Munich Germany

Department of Cardiology Instituto Cardiovascular de Buenos Aires Buenos Aires Argentina

Department of Medicine Division of Cardiology Columbia University Medical Center and NewYork Presbyterian Hospital New York New York

Herz Zentrum Bad Krozingen Bad Krozingen Germany

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