Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- chování zvířat účinky léků MeSH
- dopamin analogy a deriváty metabolismus farmakologie MeSH
- ghrelin metabolismus MeSH
- glycin aplikace a dávkování analogy a deriváty farmakologie MeSH
- krysa rodu Rattus MeSH
- kyselina 3,4-dihydroxyfenyloctová metabolismus MeSH
- kyselina homovanilová farmakologie MeSH
- mikrodialýza MeSH
- morfin aplikace a dávkování farmakologie MeSH
- nucleus accumbens účinky léků metabolismus MeSH
- odměna MeSH
- opioidní analgetika aplikace a dávkování farmakologie MeSH
- potkani Wistar MeSH
- receptory ghrelinu antagonisté a inhibitory metabolismus MeSH
- stereotypní chování účinky léků MeSH
- triazoly aplikace a dávkování farmakologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 3-methoxytyramine MeSH Prohlížeč
- dopamin MeSH
- ghrelin MeSH
- glycin MeSH
- kyselina 3,4-dihydroxyfenyloctová MeSH
- kyselina homovanilová MeSH
- morfin MeSH
- N-(1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-aminoacetamide MeSH Prohlížeč
- opioidní analgetika MeSH
- receptory ghrelinu MeSH
- triazoly MeSH
RATIONALE AND OBJECTIVES: Ghrelin, an orexigenic (appetite stimulating) peptide activates binding sites in the ventral tegmental area (a structure linked with the neural reward system) allowing it to participate in reward-seeking behavior. An increasing number of studies over the past few years have demonstrated ghrelin's role in alcohol, cocaine, and nicotine abuse. However, the role of ghrelin, in opioid effects, has rarely been examined. The aim of the present study was to ascertain whether a ghrelin antagonist (JMV2959) was able to inhibit markers of morphine-induced activation of the neural reward system, namely morphine-induced increase of dopamine in the nucleus accumbens and behavioral changes in rats. METHODS: We used in vivo microdialysis to determine changes of dopamine and its metabolites in the nucleus accumbens shell in rats following morphine (MO, 5, 10 mg/kg s.c.) administration with and without ghrelin antagonist pretreatment (JMV2959, 3, 6 mg/kg i.p., 20 min before MO). Induced behavioral changes were simultaneously monitored. RESULTS: JMV2959 significantly and dose dependently reduced MO-induced dopamine release in the nucleus accumbens shell and affected concentration of by-products associated with dopamine metabolism: 3-methoxytyramine (3-MT), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA). JMV2959 pretreatment also significantly reduced MO-induced behavioral stimulation, especially stereotyped behavior. CONCLUSIONS: Ghrelin secretagogue receptors (GHS-R1A) appear to be involved in the opioid-induced changes in the mesolimbic dopaminergic system associated with the reward processing.
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Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens
