Patterns of transmitted HIV drug resistance in Europe vary by risk group
Language English Country United States Media electronic-ecollection
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24721998
PubMed Central
PMC3983178
DOI
10.1371/journal.pone.0094495
PII: PONE-D-14-00136
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Heterosexuality statistics & numerical data MeSH
- HIV Infections drug therapy epidemiology transmission virology MeSH
- HIV-1 drug effects MeSH
- Homosexuality, Male statistics & numerical data MeSH
- Protease Inhibitors therapeutic use MeSH
- Reverse Transcriptase Inhibitors therapeutic use MeSH
- Substance Abuse, Intravenous epidemiology virology MeSH
- Anti-HIV Agents therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- Logistic Models MeSH
- Risk-Taking * MeSH
- Risk MeSH
- Sexual Behavior statistics & numerical data MeSH
- Drug Resistance, Viral * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Europe epidemiology MeSH
- Names of Substances
- Protease Inhibitors MeSH
- Reverse Transcriptase Inhibitors MeSH
- Anti-HIV Agents MeSH
BACKGROUND: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. METHODS: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. RESULTS: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (<1 year) (p<0.001). The prevalence of TDRM was highest in MSM (prevalence of 11.1%), followed by heterosexuals (6.6%) and IDU (5.1%, p<0.001). TDRM was predominantly ascribed to nucleoside reverse transcriptase inhibitors (NRTI) with a prevalence of 6.6% in MSM, 3.3% in heterosexuals and 2.0% in IDU (p = 0.001). A significant increase in resistance to non- nucleoside reverse transcriptase inhibitors (NNRTIs) and a decrease in resistance to protease inhibitors was observed in MSM (p = 0.008 and p = 0.006, respectively), but not in heterosexual patients (p = 0.68 and p = 0.14, respectively). CONCLUSIONS: MSM showed to have significantly higher TDRM prevalence compared to heterosexuals and IDU. The increasing NNRTI resistance in MSM is likely to negatively influence the therapy response of first-line therapy, as most include NNRTI drugs.
Department of GU Medicine and Infectious Diseases St James's Hospital Dublin Ireland
Department of virology Erasmus Medical Center Rotterdam the Netherlands
Department of Virology National Center of Infectious and Parasitic Diseases Sofia Bulgaria
Infectology Center of Latvia Riga Latvia
Laboratory of Retrovirology CRP Santé Luxembourg Luxembourg
Medical School University of Athens Athens Greece
Medical University Vienna Vienna Austria
Molecular Diagnostics Prof Dr Matei Bals Institute for Infectious Diseases Bucharest Romania
National Public Health Surveillance Laboratory Vilnius Lithuania
Rega Institute Katholieke Universiteit Leuven Leuven Belgium
Robert Koch Institute Berlin Germany
Section for Microbiology and Immunology The Gade Institute University of Bergen Bergen Norway
Sheba Medical Center Tel Hashomer Israel
Slovak Medical University Bratislava Slovakia
Statens Serum Institute Copenhagen Denmark
University of Belgrade School of Medicine Belgrade Serbia
University of Cyprus Nicosia Cyprus
University of Erlangen Nuremberg Erlangen Germany
University of Ljubljana Ljubljana Slovenia
University of Milan Milan Italy
Warsaw Medical University and Hospital of Infectious Diseases Warsaw Poland
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