Structural comparison of lipophosphoglycan from Leishmania turanica and L. major, two species transmitted by Phlebotomus papatasi
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24863491
DOI
10.1016/j.parint.2014.05.004
PII: S1383-5769(14)00062-2
Knihovny.cz E-resources
- Keywords
- LPG, Leishmania turanica, Phlebotomus papatasi, Sand fly–Leishmania interaction,
- MeSH
- Species Specificity MeSH
- Glycosphingolipids chemistry genetics metabolism MeSH
- Insect Vectors parasitology MeSH
- Leishmania genetics metabolism MeSH
- Phlebotomus parasitology MeSH
- Gene Expression Regulation MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Glycosphingolipids MeSH
- lipophosphonoglycan MeSH Browser
The lipophosphoglycan (LPG) of Leishmania major has a major role in the attachment to Phlebotomus papatasi midgut. Here, we investigated the comparative structural features of LPG of L. turanica, another species transmitted by P. papatasi. The mAb WIC 79.3, specific for terminal Gal(β1,3) side-chains, strongly reacted with L. turanica LPG. In contrast, L. turanica LPG was not recognized by arabinose-specific mAb 3F12. In conclusion, LPGs from L. major and L. turanica are similar, with the latter being less arabinosylated than L. major's. The high galactose content in L. turanica LPG is consistent with its predicted recognition by P. papatasi lectin PpGalec.
Centro de Pesquisas René Rachou Fundação Oswaldo Cruz 30190 002 Belo Horizonte MG Brazil
Department of Biochemistry University of Kentucky Medical Center Lexington KY 40536 USA
Department of Parasitology Faculty of Science Charles University Prague 2 128 44 Czech Republic
References provided by Crossref.org
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